Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats

Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations between edible tissues and living samples were analyzed to find ou...

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Autores principales: Lei Sun, Minjuan Zhu, Jingfei Shi, Kun Mi, Wenjing Ma, Xiangyue Xu, Hanyu Wang, Yuanhu Pan, Yanfei Tao, Zhenli Liu, Lingli Huang
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/8858f8f17aee4d128d7eb88f5edf109d
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spelling oai:doaj.org-article:8858f8f17aee4d128d7eb88f5edf109d2021-12-01T01:05:47ZExcretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats1663-981210.3389/fphar.2021.754876https://doaj.org/article/8858f8f17aee4d128d7eb88f5edf109d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphar.2021.754876/fullhttps://doaj.org/toc/1663-9812Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations between edible tissues and living samples were analyzed to find out a suitable living sample for pre-slaughter monitoring of SAL in pigs and goats. After a single oral dosage of 1.2 mg/kg SAL, approximately 70% of the dose was excreted by pigs and goats from their excreta. When pigs and goats were supplied feed containing SAL (20 mg/kg) for 14 consecutive days, high concentrations of SAL were observed in the liver and kidneys, and the longest persistence was observed in hair. Unlike pigs, SAL was presented primarily as conjugated SAL in goats. Excellent concentration correlations of SAL were observed between urine and edible tissues both in pigs and goats, and in addition, good correlations also were found between hair and edible tissues in pigs and between feces and edible tissues in goats. Hence, urine and hair could accurately predict SAL concentrations in edible tissues of pigs, whereas feces and urine were satisfactory for predicting SAL concentrations in edible tissues of goats. These data make it possible for pre-slaughter monitoring of SAL residues in the edible tissues of pigs and goats.Lei SunLei SunLei SunMinjuan ZhuMinjuan ZhuMinjuan ZhuJingfei ShiJingfei ShiJingfei ShiKun MiKun MiWenjing MaWenjing MaWenjing MaXiangyue XuXiangyue XuXiangyue XuHanyu WangHanyu WangHanyu WangYuanhu PanYuanhu PanYuanhu PanYanfei TaoYanfei TaoYanfei TaoZhenli LiuZhenli LiuZhenli LiuLingli HuangLingli HuangLingli HuangFrontiers Media S.A.articleSALpiggoatexcretiondepletionpre-slaughter monitoringTherapeutics. PharmacologyRM1-950ENFrontiers in Pharmacology, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic SAL
pig
goat
excretion
depletion
pre-slaughter monitoring
Therapeutics. Pharmacology
RM1-950
spellingShingle SAL
pig
goat
excretion
depletion
pre-slaughter monitoring
Therapeutics. Pharmacology
RM1-950
Lei Sun
Lei Sun
Lei Sun
Minjuan Zhu
Minjuan Zhu
Minjuan Zhu
Jingfei Shi
Jingfei Shi
Jingfei Shi
Kun Mi
Kun Mi
Wenjing Ma
Wenjing Ma
Wenjing Ma
Xiangyue Xu
Xiangyue Xu
Xiangyue Xu
Hanyu Wang
Hanyu Wang
Hanyu Wang
Yuanhu Pan
Yuanhu Pan
Yuanhu Pan
Yanfei Tao
Yanfei Tao
Yanfei Tao
Zhenli Liu
Zhenli Liu
Zhenli Liu
Lingli Huang
Lingli Huang
Lingli Huang
Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
description Illegal use of salbutamol (SAL), a β-adrenergic leanness-enhancing agent, has posed potential threat to human health in China. The excretion and depletion of SAL in pigs and goats were investigated, and the concentration correlations between edible tissues and living samples were analyzed to find out a suitable living sample for pre-slaughter monitoring of SAL in pigs and goats. After a single oral dosage of 1.2 mg/kg SAL, approximately 70% of the dose was excreted by pigs and goats from their excreta. When pigs and goats were supplied feed containing SAL (20 mg/kg) for 14 consecutive days, high concentrations of SAL were observed in the liver and kidneys, and the longest persistence was observed in hair. Unlike pigs, SAL was presented primarily as conjugated SAL in goats. Excellent concentration correlations of SAL were observed between urine and edible tissues both in pigs and goats, and in addition, good correlations also were found between hair and edible tissues in pigs and between feces and edible tissues in goats. Hence, urine and hair could accurately predict SAL concentrations in edible tissues of pigs, whereas feces and urine were satisfactory for predicting SAL concentrations in edible tissues of goats. These data make it possible for pre-slaughter monitoring of SAL residues in the edible tissues of pigs and goats.
format article
author Lei Sun
Lei Sun
Lei Sun
Minjuan Zhu
Minjuan Zhu
Minjuan Zhu
Jingfei Shi
Jingfei Shi
Jingfei Shi
Kun Mi
Kun Mi
Wenjing Ma
Wenjing Ma
Wenjing Ma
Xiangyue Xu
Xiangyue Xu
Xiangyue Xu
Hanyu Wang
Hanyu Wang
Hanyu Wang
Yuanhu Pan
Yuanhu Pan
Yuanhu Pan
Yanfei Tao
Yanfei Tao
Yanfei Tao
Zhenli Liu
Zhenli Liu
Zhenli Liu
Lingli Huang
Lingli Huang
Lingli Huang
author_facet Lei Sun
Lei Sun
Lei Sun
Minjuan Zhu
Minjuan Zhu
Minjuan Zhu
Jingfei Shi
Jingfei Shi
Jingfei Shi
Kun Mi
Kun Mi
Wenjing Ma
Wenjing Ma
Wenjing Ma
Xiangyue Xu
Xiangyue Xu
Xiangyue Xu
Hanyu Wang
Hanyu Wang
Hanyu Wang
Yuanhu Pan
Yuanhu Pan
Yuanhu Pan
Yanfei Tao
Yanfei Tao
Yanfei Tao
Zhenli Liu
Zhenli Liu
Zhenli Liu
Lingli Huang
Lingli Huang
Lingli Huang
author_sort Lei Sun
title Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
title_short Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
title_full Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
title_fullStr Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
title_full_unstemmed Excretion and Residual Concentration Correlations of Salbutamol Between Edible Tissues and Living Samples in Pigs and Goats
title_sort excretion and residual concentration correlations of salbutamol between edible tissues and living samples in pigs and goats
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/8858f8f17aee4d128d7eb88f5edf109d
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