MHC class II complexes sample intermediate states along the peptide exchange pathway

MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII pepti...

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Autores principales:	Marek Wieczorek, Jana Sticht, Sebastian Stolzenberg, Sebastian Günther, Christoph Wehmeyer, Zeina El Habre, Miguel Álvaro-Benito, Frank Noé, Christian Freund
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/885b930885fb44358b5880c82938cbe4
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spelling	oai:doaj.org-article:885b930885fb44358b5880c82938cbe42021-12-02T17:33:20ZMHC class II complexes sample intermediate states along the peptide exchange pathway10.1038/ncomms132242041-1723https://doaj.org/article/885b930885fb44358b5880c82938cbe42016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13224https://doaj.org/toc/2041-1723MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII peptide exchange.Marek WieczorekJana StichtSebastian StolzenbergSebastian GüntherChristoph WehmeyerZeina El HabreMiguel Álvaro-BenitoFrank NoéChristian FreundNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marek Wieczorek Jana Sticht Sebastian Stolzenberg Sebastian Günther Christoph Wehmeyer Zeina El Habre Miguel Álvaro-Benito Frank Noé Christian Freund MHC class II complexes sample intermediate states along the peptide exchange pathway
description	MHCII proteins bind and present both foreign and self-antigens to potentially activate CD4+ T cells via cognate T cell receptors (TCRs) during the adaptive immune response. Here, the authors combine NMR-detected H/D exchange with Markov modelling analysis to shed light on the dynamics of MHCII peptide exchange.
format	article
author	Marek Wieczorek Jana Sticht Sebastian Stolzenberg Sebastian Günther Christoph Wehmeyer Zeina El Habre Miguel Álvaro-Benito Frank Noé Christian Freund
author_facet	Marek Wieczorek Jana Sticht Sebastian Stolzenberg Sebastian Günther Christoph Wehmeyer Zeina El Habre Miguel Álvaro-Benito Frank Noé Christian Freund
author_sort	Marek Wieczorek
title	MHC class II complexes sample intermediate states along the peptide exchange pathway
title_short	MHC class II complexes sample intermediate states along the peptide exchange pathway
title_full	MHC class II complexes sample intermediate states along the peptide exchange pathway
title_fullStr	MHC class II complexes sample intermediate states along the peptide exchange pathway
title_full_unstemmed	MHC class II complexes sample intermediate states along the peptide exchange pathway
title_sort	mhc class ii complexes sample intermediate states along the peptide exchange pathway
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/885b930885fb44358b5880c82938cbe4
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MHC class II complexes sample intermediate states along the peptide exchange pathway

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