Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the...

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Autores principales:	Ying Li, Juan Qin, Yinghui Cheng, Dong Lv, Meng Li, Yanxia Qi, Jing Lan, Qiancheng Zhao, Zhibo Li
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	marine sulfate polysaccharides metabolic syndrome gut microbiota functional foods sulfate Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/885d8d0644044c28a4766709fd7f35ad
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spelling	oai:doaj.org-article:885d8d0644044c28a4766709fd7f35ad2021-11-25T18:12:47ZMarine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review10.3390/md191106081660-3397https://doaj.org/article/885d8d0644044c28a4766709fd7f35ad2021-10-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/608https://doaj.org/toc/1660-3397Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.Ying LiJuan QinYinghui ChengDong LvMeng LiYanxia QiJing LanQiancheng ZhaoZhibo LiMDPI AGarticlemarine sulfate polysaccharidesmetabolic syndromegut microbiotafunctional foodssulfateBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 608, p 608 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	marine sulfate polysaccharides metabolic syndrome gut microbiota functional foods sulfate Biology (General) QH301-705.5
spellingShingle	marine sulfate polysaccharides metabolic syndrome gut microbiota functional foods sulfate Biology (General) QH301-705.5 Ying Li Juan Qin Yinghui Cheng Dong Lv Meng Li Yanxia Qi Jing Lan Qiancheng Zhao Zhibo Li Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review
description	Metabolic syndrome is the pathological basis of cardiovascular and cerebrovascular diseases and type 2 diabetes. With the prevalence of modern lifestyles, the incidence of metabolic syndrome has risen rapidly. In recent years, marine sulfate polysaccharides (MSPs) have shown positive effects in the prevention and treatment of metabolic syndrome, and they mainly come from seaweeds and marine animals. MSPs are rich in sulfate and have stronger biological activity compared with terrestrial polysaccharides. MSPs can alleviate metabolic syndrome by regulating glucose metabolism and lipid metabolism. In addition, MSPs prevent and treat metabolic syndrome by interacting with gut microbiota. MSPs can be degraded by gut microbes to produce metabolites such as short chain fatty acids (SCFAs) and free sulfate and affect the composition of gut microbiota. The difference between MSPs and other polysaccharides lies in the sulfation pattern and sulfate content, therefore, which is very important for anti-metabolic syndrome activity of MSPs. This review summarizes the latest findings on effects of MSPs on metabolic syndrome, mechanisms of MSPs in treatment/prevention of metabolic syndrome, interactions between MSPs and gut microbiota, and the role of sulfate group and sulfation pattern in MSPs activity. However, more clinical trials are needed to confirm the potential preventive and therapeutic effects on human body. It may be a better choice to develop new functional foods containing MSPs for dietary intervention in metabolic syndrome.
format	article
author	Ying Li Juan Qin Yinghui Cheng Dong Lv Meng Li Yanxia Qi Jing Lan Qiancheng Zhao Zhibo Li
author_facet	Ying Li Juan Qin Yinghui Cheng Dong Lv Meng Li Yanxia Qi Jing Lan Qiancheng Zhao Zhibo Li
author_sort	Ying Li
title	Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review
title_short	Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review
title_full	Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review
title_fullStr	Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review
title_full_unstemmed	Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review
title_sort	marine sulfated polysaccharides: preventive and therapeutic effects on metabolic syndrome: a review
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/885d8d0644044c28a4766709fd7f35ad
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Marine Sulfated Polysaccharides: Preventive and Therapeutic Effects on Metabolic Syndrome: A Review

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