Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19

Abstract COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic rotational thrombelastometry (ROTEM)...

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Autores principales:	Abakar Magomedov, Daniel Zickler, Stoyan Karaivanov, Annika Kurreck, Frédéric H. Münch, Julian Kamhieh-Milz, Caroline Ferse, Andreas Kahl, Sophie K. Piper, Kai-Uwe Eckardt, Thomas Dörner, Jan Matthias Kruse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/885f70bb2e6d41c7a45fd6cabd7e91db
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spelling	oai:doaj.org-article:885f70bb2e6d41c7a45fd6cabd7e91db2021-12-02T17:12:25ZViscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-1910.1038/s41598-021-92683-12045-2322https://doaj.org/article/885f70bb2e6d41c7a45fd6cabd7e91db2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92683-1https://doaj.org/toc/2045-2322Abstract COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic rotational thrombelastometry (ROTEM) in a single center cohort of 13 critical ill patients and performed follow up examinations three months after discharge from ICU. We found clear signs of a hypercoagulable state due to severe hypofibrinolysis and a high rate of thromboembolic complications during the phase of acute illness. Three month follow up revealed normalization of the initial coagulation abnormality and no evidence of venous thrombosis in all thirteen patients. In our cohort the coagulation profile was completely normalized three months after COVID-19. Based on these findings, discontinuation of anticoagulation can be discussed in patients with complete venous reperfusion.Abakar MagomedovDaniel ZicklerStoyan KaraivanovAnnika KurreckFrédéric H. MünchJulian Kamhieh-MilzCaroline FerseAndreas KahlSophie K. PiperKai-Uwe EckardtThomas DörnerJan Matthias KruseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Abakar Magomedov Daniel Zickler Stoyan Karaivanov Annika Kurreck Frédéric H. Münch Julian Kamhieh-Milz Caroline Ferse Andreas Kahl Sophie K. Piper Kai-Uwe Eckardt Thomas Dörner Jan Matthias Kruse Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
description	Abstract COVID 19 is associated with a hypercoagulable state and frequent thromboembolic complications. For how long this acquired abnormality lasts potentially requiring preventive measures, such as anticoagulation remains to be delineated. We used viscoelastic rotational thrombelastometry (ROTEM) in a single center cohort of 13 critical ill patients and performed follow up examinations three months after discharge from ICU. We found clear signs of a hypercoagulable state due to severe hypofibrinolysis and a high rate of thromboembolic complications during the phase of acute illness. Three month follow up revealed normalization of the initial coagulation abnormality and no evidence of venous thrombosis in all thirteen patients. In our cohort the coagulation profile was completely normalized three months after COVID-19. Based on these findings, discontinuation of anticoagulation can be discussed in patients with complete venous reperfusion.
format	article
author	Abakar Magomedov Daniel Zickler Stoyan Karaivanov Annika Kurreck Frédéric H. Münch Julian Kamhieh-Milz Caroline Ferse Andreas Kahl Sophie K. Piper Kai-Uwe Eckardt Thomas Dörner Jan Matthias Kruse
author_facet	Abakar Magomedov Daniel Zickler Stoyan Karaivanov Annika Kurreck Frédéric H. Münch Julian Kamhieh-Milz Caroline Ferse Andreas Kahl Sophie K. Piper Kai-Uwe Eckardt Thomas Dörner Jan Matthias Kruse
author_sort	Abakar Magomedov
title	Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
title_short	Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
title_full	Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
title_fullStr	Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
title_full_unstemmed	Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19
title_sort	viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe covid-19
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/885f70bb2e6d41c7a45fd6cabd7e91db
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Viscoelastic testing reveals normalization of the coagulation profile 12 weeks after severe COVID-19

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