System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) is an aggressive malignant tumor with a poor prognosis. Reactive oxygen species (ROS) play an important role in tumors; however, the role of ROS-related genes is still unclear in HCC. Therefore, we analyzed the role of ROS-related genes in HCC via bioinformatics method...

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Autores principales:	Jun Hui Xu, Yong Jun Guan, Zhen Dong Qiu, Xin Zhang, Liu Liu Zi, Yu Zhou, Chen Chen, Jia Yu, Yi Chao Zhang, Wei Xing Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/88624726297344eaaa9b57a9cdc72588
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spelling	oai:doaj.org-article:88624726297344eaaa9b57a9cdc725882021-11-22T01:10:30ZSystem Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma1942-099410.1155/2021/6485871https://doaj.org/article/88624726297344eaaa9b57a9cdc725882021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/6485871https://doaj.org/toc/1942-0994Hepatocellular carcinoma (HCC) is an aggressive malignant tumor with a poor prognosis. Reactive oxygen species (ROS) play an important role in tumors; however, the role of ROS-related genes is still unclear in HCC. Therefore, we analyzed the role of ROS-related genes in HCC via bioinformatics methods. Firstly, a prognosis model was constructed using LASSO Cox regression and multivariate analyses. We also investigated the potential function of the ROS-related genes and the correlation with immune infiltration, tumor stemness, and drug sensitivity. ICGC database was used for validation. Secondly, we further analyzed the role of 11 ROS-related genes in HCC. As a member of ROS gene family, the role of STK25 has remained unclear in HCC. We explored the biological function of STK25 using in vitro experiments. The present study was the first to construct a ROS-related prognostic model in HCC. The correlation of ROS-related genes with immune infiltration, tumor stemness, and drug sensitivity was dissected. Furthermore, we demonstrated that STK25 knockdown could increase the proliferation, migration, and invasion capacity of HCC cells.Jun Hui XuYong Jun GuanZhen Dong QiuXin ZhangLiu Liu ZiYu ZhouChen ChenJia YuYi Chao ZhangWei Xing WangHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Jun Hui Xu Yong Jun Guan Zhen Dong Qiu Xin Zhang Liu Liu Zi Yu Zhou Chen Chen Jia Yu Yi Chao Zhang Wei Xing Wang System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma
description	Hepatocellular carcinoma (HCC) is an aggressive malignant tumor with a poor prognosis. Reactive oxygen species (ROS) play an important role in tumors; however, the role of ROS-related genes is still unclear in HCC. Therefore, we analyzed the role of ROS-related genes in HCC via bioinformatics methods. Firstly, a prognosis model was constructed using LASSO Cox regression and multivariate analyses. We also investigated the potential function of the ROS-related genes and the correlation with immune infiltration, tumor stemness, and drug sensitivity. ICGC database was used for validation. Secondly, we further analyzed the role of 11 ROS-related genes in HCC. As a member of ROS gene family, the role of STK25 has remained unclear in HCC. We explored the biological function of STK25 using in vitro experiments. The present study was the first to construct a ROS-related prognostic model in HCC. The correlation of ROS-related genes with immune infiltration, tumor stemness, and drug sensitivity was dissected. Furthermore, we demonstrated that STK25 knockdown could increase the proliferation, migration, and invasion capacity of HCC cells.
format	article
author	Jun Hui Xu Yong Jun Guan Zhen Dong Qiu Xin Zhang Liu Liu Zi Yu Zhou Chen Chen Jia Yu Yi Chao Zhang Wei Xing Wang
author_facet	Jun Hui Xu Yong Jun Guan Zhen Dong Qiu Xin Zhang Liu Liu Zi Yu Zhou Chen Chen Jia Yu Yi Chao Zhang Wei Xing Wang
author_sort	Jun Hui Xu
title	System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma
title_short	System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma
title_full	System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma
title_fullStr	System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma
title_full_unstemmed	System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma
title_sort	system analysis of ros-related genes in the prognosis, immune infiltration, and drug sensitivity in hepatocellular carcinoma
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/88624726297344eaaa9b57a9cdc72588
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System Analysis of ROS-Related Genes in the Prognosis, Immune Infiltration, and Drug Sensitivity in Hepatocellular Carcinoma

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