Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying

The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance). Riton...

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Autores principales:	Barbara V. Schönfeld, Ulrich Westedt, Karl G. Wagner
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Ritonavir Hot-melt extrusion Spray drying Vacuum drum drying Amorphous solid dispersion Compression analysis Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/8862951727d84012b6a643ea188fb055
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spelling	oai:doaj.org-article:8862951727d84012b6a643ea188fb0552021-11-26T04:39:44ZCompression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying2590-156710.1016/j.ijpx.2021.100102https://doaj.org/article/8862951727d84012b6a643ea188fb0552021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590156721000311https://doaj.org/toc/2590-1567The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance). Ritonavir (15% w/w) in a copovidone/sorbitan monolaurate matrix was used as ASD model system. The pure ASDs and respective tablet blends (TB) (addition of filler, glidant, lubricant) were investigated. Milled extrudate showed superior powder properties (e.g., flowability, bulk density) compared to VDD and SD, which could be compensated by the addition of 12.9% outer phase. Advantageously, the VDD intermediate was directly compressible, whereas the SD material was not, resulting in tablets with defects based on a high degree of elastic recovery. Compared to HME, the VDD material showed superior tabletability when formulated as TB, resulting in stronger compacts at even lower solid fraction values. Despite the differences in tablet processing, tablets showed similar tablet performance in terms of disintegration and dissolution independent of the ASD origin. In conclusion, VDD is a valid alternative to manufacture ASDs. VDD offered advantageous downstream processability compared to SD: less solvents and process steps required (no second drying), improved powder properties and suitable for direct compression.Barbara V. SchönfeldUlrich WestedtKarl G. WagnerElsevierarticleRitonavirHot-melt extrusionSpray dryingVacuum drum dryingAmorphous solid dispersionCompression analysisPharmacy and materia medicaRS1-441ENInternational Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100102- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ritonavir Hot-melt extrusion Spray drying Vacuum drum drying Amorphous solid dispersion Compression analysis Pharmacy and materia medica RS1-441
spellingShingle	Ritonavir Hot-melt extrusion Spray drying Vacuum drum drying Amorphous solid dispersion Compression analysis Pharmacy and materia medica RS1-441 Barbara V. Schönfeld Ulrich Westedt Karl G. Wagner Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
description	The present study explored vacuum drum drying (VDD) as an alternative technology for amorphous solid dispersions (ASDs) manufacture compared to hot-melt extrusion (HME) and spray drying (SD) focusing on downstream processability (powder properties, compression behavior and tablet performance). Ritonavir (15% w/w) in a copovidone/sorbitan monolaurate matrix was used as ASD model system. The pure ASDs and respective tablet blends (TB) (addition of filler, glidant, lubricant) were investigated. Milled extrudate showed superior powder properties (e.g., flowability, bulk density) compared to VDD and SD, which could be compensated by the addition of 12.9% outer phase. Advantageously, the VDD intermediate was directly compressible, whereas the SD material was not, resulting in tablets with defects based on a high degree of elastic recovery. Compared to HME, the VDD material showed superior tabletability when formulated as TB, resulting in stronger compacts at even lower solid fraction values. Despite the differences in tablet processing, tablets showed similar tablet performance in terms of disintegration and dissolution independent of the ASD origin. In conclusion, VDD is a valid alternative to manufacture ASDs. VDD offered advantageous downstream processability compared to SD: less solvents and process steps required (no second drying), improved powder properties and suitable for direct compression.
format	article
author	Barbara V. Schönfeld Ulrich Westedt Karl G. Wagner
author_facet	Barbara V. Schönfeld Ulrich Westedt Karl G. Wagner
author_sort	Barbara V. Schönfeld
title	Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
title_short	Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
title_full	Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
title_fullStr	Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
title_full_unstemmed	Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
title_sort	compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/8862951727d84012b6a643ea188fb055
work_keys_str_mv	AT barbaravschonfeld compressionofamorphoussoliddispersionspreparedbyhotmeltextrusionspraydryingandvacuumdrumdrying AT ulrichwestedt compressionofamorphoussoliddispersionspreparedbyhotmeltextrusionspraydryingandvacuumdrumdrying AT karlgwagner compressionofamorphoussoliddispersionspreparedbyhotmeltextrusionspraydryingandvacuumdrumdrying
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Compression of amorphous solid dispersions prepared by hot-melt extrusion, spray drying and vacuum drum drying

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