Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations

Abstract Due to their antimicrobial properties, silver nanoparticles (AgNPs) are used in a wide range of consumer products that includes topical wound dressings, coatings for biomedical devices, and food-packaging to extend the shelf-life. Despite their beneficial antimicrobial effects, developmenta...

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Autores principales:	Zhen Lyu, Shreya Ghoshdastidar, Karamkolly R. Rekha, Dhananjay Suresh, Jiude Mao, Nathan Bivens, Raghuraman Kannan, Trupti Joshi, Cheryl S. Rosenfeld, Anandhi Upendran
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/886378956f5745e2ac3dfc5d524755dc
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spelling	oai:doaj.org-article:886378956f5745e2ac3dfc5d524755dc2021-12-02T16:35:56ZDevelopmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations10.1038/s41598-021-85919-72045-2322https://doaj.org/article/886378956f5745e2ac3dfc5d524755dc2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85919-7https://doaj.org/toc/2045-2322Abstract Due to their antimicrobial properties, silver nanoparticles (AgNPs) are used in a wide range of consumer products that includes topical wound dressings, coatings for biomedical devices, and food-packaging to extend the shelf-life. Despite their beneficial antimicrobial effects, developmental exposure to such AgNPs may lead to gut dysbiosis and long-term health consequences in exposed offspring. AgNPs can cross the placenta and blood–brain-barrier to translocate in the brain of offspring. The underlying hypothesis tested in the current study was that developmental exposure of male and female mice to AgNPs disrupts the microbiome–gut–brain axis. To examine for such effects, C57BL6 female mice were exposed orally to AgNPs at a dose of 3 mg/kg BW or vehicle control 2 weeks prior to breeding and throughout gestation. Male and female offspring were tested in various mazes that measure different behavioral domains, and the gut microbial profiles were surveyed from 30 through 120 days of age. Our study results suggest that developmental exposure results in increased likelihood of engaging in repetitive behaviors and reductions in resident microglial cells. Echo-MRI results indicate increased body fat in offspring exposed to AgNPs exhibit. Coprobacillus spp., Mucispirillum spp., and Bifidobacterium spp. were reduced, while Prevotella spp., Bacillus spp., Planococcaceae, Staphylococcus spp., Enterococcus spp., and Ruminococcus spp. were increased in those developmentally exposed to NPs. These bacterial changes were linked to behavioral and metabolic alterations. In conclusion, developmental exposure of AgNPs results in long term gut dysbiosis, body fat increase and neurobehavioral alterations in offspring.Zhen LyuShreya GhoshdastidarKaramkolly R. RekhaDhananjay SureshJiude MaoNathan BivensRaghuraman KannanTrupti JoshiCheryl S. RosenfeldAnandhi UpendranNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen Lyu Shreya Ghoshdastidar Karamkolly R. Rekha Dhananjay Suresh Jiude Mao Nathan Bivens Raghuraman Kannan Trupti Joshi Cheryl S. Rosenfeld Anandhi Upendran Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
description	Abstract Due to their antimicrobial properties, silver nanoparticles (AgNPs) are used in a wide range of consumer products that includes topical wound dressings, coatings for biomedical devices, and food-packaging to extend the shelf-life. Despite their beneficial antimicrobial effects, developmental exposure to such AgNPs may lead to gut dysbiosis and long-term health consequences in exposed offspring. AgNPs can cross the placenta and blood–brain-barrier to translocate in the brain of offspring. The underlying hypothesis tested in the current study was that developmental exposure of male and female mice to AgNPs disrupts the microbiome–gut–brain axis. To examine for such effects, C57BL6 female mice were exposed orally to AgNPs at a dose of 3 mg/kg BW or vehicle control 2 weeks prior to breeding and throughout gestation. Male and female offspring were tested in various mazes that measure different behavioral domains, and the gut microbial profiles were surveyed from 30 through 120 days of age. Our study results suggest that developmental exposure results in increased likelihood of engaging in repetitive behaviors and reductions in resident microglial cells. Echo-MRI results indicate increased body fat in offspring exposed to AgNPs exhibit. Coprobacillus spp., Mucispirillum spp., and Bifidobacterium spp. were reduced, while Prevotella spp., Bacillus spp., Planococcaceae, Staphylococcus spp., Enterococcus spp., and Ruminococcus spp. were increased in those developmentally exposed to NPs. These bacterial changes were linked to behavioral and metabolic alterations. In conclusion, developmental exposure of AgNPs results in long term gut dysbiosis, body fat increase and neurobehavioral alterations in offspring.
format	article
author	Zhen Lyu Shreya Ghoshdastidar Karamkolly R. Rekha Dhananjay Suresh Jiude Mao Nathan Bivens Raghuraman Kannan Trupti Joshi Cheryl S. Rosenfeld Anandhi Upendran
author_facet	Zhen Lyu Shreya Ghoshdastidar Karamkolly R. Rekha Dhananjay Suresh Jiude Mao Nathan Bivens Raghuraman Kannan Trupti Joshi Cheryl S. Rosenfeld Anandhi Upendran
author_sort	Zhen Lyu
title	Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
title_short	Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
title_full	Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
title_fullStr	Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
title_full_unstemmed	Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
title_sort	developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/886378956f5745e2ac3dfc5d524755dc
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Developmental exposure to silver nanoparticles leads to long term gut dysbiosis and neurobehavioral alterations

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