Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows

Circular RNAs (circRNAs), as miRNA sponges, have been found to participate in transcriptional control and many important biological processes. Heat stress (HS) severely affects feed intake and milk production of sows. However, the expression and function of circRNAs in the hypothalamus of sows and w...

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Autores principales:	Yifan Ni, Jianfeng Cai, Qiangqiang Chen, Fen Wu, Jinping Hu, Jinzhi Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2021
Materias:	circular rna hypothalamus heat stress sows transcriptome analysis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/88676b9b49424c47bdbe1051506f7eec
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spelling	oai:doaj.org-article:88676b9b49424c47bdbe1051506f7eec2021-11-26T11:19:47ZCircular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows0971-21190974-184410.1080/09712119.2021.2005070https://doaj.org/article/88676b9b49424c47bdbe1051506f7eec2021-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09712119.2021.2005070https://doaj.org/toc/0971-2119https://doaj.org/toc/0974-1844Circular RNAs (circRNAs), as miRNA sponges, have been found to participate in transcriptional control and many important biological processes. Heat stress (HS) severely affects feed intake and milk production of sows. However, the expression and function of circRNAs in the hypothalamus of sows and whether they are involved in the adaptation to HS have not been explored. In this study, RNA sequencing and functional analysis were performed to explore the expression and function of circRNAs in the hypothalamus of heat-stressed sows. Toally, 38,143 circRNAs were identified from the hypothalamus of heat-stressed sows, among which 307 circRNAs (170 upregulated and 137 downregulated) were significantly differentially expressed (DE) in the HS groups compared to the control groups. Their host genes are involved in the cellular component organization or biogenesis, metabolic process, and cellular metabolic process, the MAPK signalling pathway and the TGF-β signalling pathway. And a total of 307 DE circRNAs were found to act as sponges for 457 miRNAs. This research explored the expression profiles of circRNAs in the hypothalamus of heat-stressed sows, which will provide basic data for further investigation of the biological function and the regulatory role of circRNAs in the heat-stressed sows.Yifan NiJianfeng CaiQiangqiang ChenFen WuJinping HuJinzhi ZhangTaylor & Francis Grouparticlecircular rnahypothalamusheat stresssowstranscriptome analysisVeterinary medicineSF600-1100ENJournal of Applied Animal Research, Vol 49, Iss 1, Pp 440-446 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	circular rna hypothalamus heat stress sows transcriptome analysis Veterinary medicine SF600-1100
spellingShingle	circular rna hypothalamus heat stress sows transcriptome analysis Veterinary medicine SF600-1100 Yifan Ni Jianfeng Cai Qiangqiang Chen Fen Wu Jinping Hu Jinzhi Zhang Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows
description	Circular RNAs (circRNAs), as miRNA sponges, have been found to participate in transcriptional control and many important biological processes. Heat stress (HS) severely affects feed intake and milk production of sows. However, the expression and function of circRNAs in the hypothalamus of sows and whether they are involved in the adaptation to HS have not been explored. In this study, RNA sequencing and functional analysis were performed to explore the expression and function of circRNAs in the hypothalamus of heat-stressed sows. Toally, 38,143 circRNAs were identified from the hypothalamus of heat-stressed sows, among which 307 circRNAs (170 upregulated and 137 downregulated) were significantly differentially expressed (DE) in the HS groups compared to the control groups. Their host genes are involved in the cellular component organization or biogenesis, metabolic process, and cellular metabolic process, the MAPK signalling pathway and the TGF-β signalling pathway. And a total of 307 DE circRNAs were found to act as sponges for 457 miRNAs. This research explored the expression profiles of circRNAs in the hypothalamus of heat-stressed sows, which will provide basic data for further investigation of the biological function and the regulatory role of circRNAs in the heat-stressed sows.
format	article
author	Yifan Ni Jianfeng Cai Qiangqiang Chen Fen Wu Jinping Hu Jinzhi Zhang
author_facet	Yifan Ni Jianfeng Cai Qiangqiang Chen Fen Wu Jinping Hu Jinzhi Zhang
author_sort	Yifan Ni
title	Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows
title_short	Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows
title_full	Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows
title_fullStr	Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows
title_full_unstemmed	Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows
title_sort	circular rna transcriptome analysis responses to heat stress in the hypothalamus of sows
publisher	Taylor & Francis Group
publishDate	2021
url	https://doaj.org/article/88676b9b49424c47bdbe1051506f7eec
work_keys_str_mv	AT yifanni circularrnatranscriptomeanalysisresponsestoheatstressinthehypothalamusofsows AT jianfengcai circularrnatranscriptomeanalysisresponsestoheatstressinthehypothalamusofsows AT qiangqiangchen circularrnatranscriptomeanalysisresponsestoheatstressinthehypothalamusofsows AT fenwu circularrnatranscriptomeanalysisresponsestoheatstressinthehypothalamusofsows AT jinpinghu circularrnatranscriptomeanalysisresponsestoheatstressinthehypothalamusofsows AT jinzhizhang circularrnatranscriptomeanalysisresponsestoheatstressinthehypothalamusofsows
_version_	1718409546059218944

Circular RNA transcriptome analysis responses to heat stress in the hypothalamus of sows

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