Annotating Protein Functional Residues by Coupling High-Throughput Fitness Profile and Homologous-Structure Analysis

ABSTRACT Identification and annotation of functional residues are fundamental questions in protein sequence analysis. Sequence and structure conservation provides valuable information to tackle these questions. It is, however, limited by the incomplete sampling of sequence space in natural evolution...

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Auteurs principaux: Yushen Du, Nicholas C. Wu, Lin Jiang, Tianhao Zhang, Danyang Gong, Sara Shu, Ting-Ting Wu, Ren Sun
Format: article
Langue:EN
Publié: American Society for Microbiology 2016
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Accès en ligne:https://doaj.org/article/8867eb0a00a8416e92cd0993397b84bb
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