Albumin inhibits the nuclear translocation of Smad3 via interleukin-1beta signaling in hepatic stellate cells

Albumin inhibits the nuclear translocation of Smad3 via interleukin-1beta signaling in hepatic stellate cells

Abstract Activation of quiescent hepatic stellate cells (HSCs) to myofibroblasts plays a key role in liver fibrosis. We had previously shown that albumin and its derivative, R-III (a retinol-binding protein—albumin domain III fusion protein), inhibited HSC activation by sequestering retinoic acid (R...

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Autores principales: Ji Hoon Park, Janghyun Kim, So-Young Choi, Boram Lee, Jung-Eun Lee, Heekyung Park, Ji Wook Moon, Sun-Hwa Park, Jae Min Lee, Hong Sik Lee, Junseo Oh
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/886a0473bd5e4724bb9ad46c21bd2971
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