Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus

Abstract Wolbachia, an intracellular endosymbiont present in up to 70% of all insect species, has been suggested as a sustainable strategy for the control of arboviruses such as Dengue, Zika and Chikungunya. As Mayaro virus outbreaks have also been reported in Latin American countries, the objective...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Thiago Nunes Pereira, Marcele Neves Rocha, Pedro Henrique Ferreira Sucupira, Fabiano Duarte Carvalho, Luciano Andrade Moreira
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/886aa1247bbb4fbe893f843ef437d56b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:886aa1247bbb4fbe893f843ef437d56b
record_format	dspace
spelling	oai:doaj.org-article:886aa1247bbb4fbe893f843ef437d56b2021-12-02T12:32:22ZWolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus10.1038/s41598-018-25236-82045-2322https://doaj.org/article/886aa1247bbb4fbe893f843ef437d56b2018-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-25236-8https://doaj.org/toc/2045-2322Abstract Wolbachia, an intracellular endosymbiont present in up to 70% of all insect species, has been suggested as a sustainable strategy for the control of arboviruses such as Dengue, Zika and Chikungunya. As Mayaro virus outbreaks have also been reported in Latin American countries, the objective of this study was to evaluate the vector competence of Brazilian field-collected Ae. aegypti and the impact of Wolbachia (wMel strain) upon this virus. Our in vitro studies with Aag2 cells showed that Mayaro virus can rapidly multiply, whereas in wMel-infected Aag2 cells, viral growth was significantly impaired. In addition, C6/36 cells seem to have alterations when infected by Mayaro virus. In vivo experiments showed that field-collected Ae. aegypti mosquitoes are highly permissive to Mayaro virus infection, and high viral prevalence was observed in the saliva. On the other hand, Wolbachia-harboring mosquitoes showed significantly impaired capability to transmit Mayaro virus. Our results suggest that the use of Wolbachia-harboring mosquitoes may represent an effective mechanism for the reduction of Mayaro virus transmission throughout Latin America.Thiago Nunes PereiraMarcele Neves RochaPedro Henrique Ferreira SucupiraFabiano Duarte CarvalhoLuciano Andrade MoreiraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Thiago Nunes Pereira Marcele Neves Rocha Pedro Henrique Ferreira Sucupira Fabiano Duarte Carvalho Luciano Andrade Moreira Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus
description	Abstract Wolbachia, an intracellular endosymbiont present in up to 70% of all insect species, has been suggested as a sustainable strategy for the control of arboviruses such as Dengue, Zika and Chikungunya. As Mayaro virus outbreaks have also been reported in Latin American countries, the objective of this study was to evaluate the vector competence of Brazilian field-collected Ae. aegypti and the impact of Wolbachia (wMel strain) upon this virus. Our in vitro studies with Aag2 cells showed that Mayaro virus can rapidly multiply, whereas in wMel-infected Aag2 cells, viral growth was significantly impaired. In addition, C6/36 cells seem to have alterations when infected by Mayaro virus. In vivo experiments showed that field-collected Ae. aegypti mosquitoes are highly permissive to Mayaro virus infection, and high viral prevalence was observed in the saliva. On the other hand, Wolbachia-harboring mosquitoes showed significantly impaired capability to transmit Mayaro virus. Our results suggest that the use of Wolbachia-harboring mosquitoes may represent an effective mechanism for the reduction of Mayaro virus transmission throughout Latin America.
format	article
author	Thiago Nunes Pereira Marcele Neves Rocha Pedro Henrique Ferreira Sucupira Fabiano Duarte Carvalho Luciano Andrade Moreira
author_facet	Thiago Nunes Pereira Marcele Neves Rocha Pedro Henrique Ferreira Sucupira Fabiano Duarte Carvalho Luciano Andrade Moreira
author_sort	Thiago Nunes Pereira
title	Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus
title_short	Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus
title_full	Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus
title_fullStr	Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus
title_full_unstemmed	Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus
title_sort	wolbachia significantly impacts the vector competence of aedes aegypti for mayaro virus
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/886aa1247bbb4fbe893f843ef437d56b
work_keys_str_mv	AT thiagonunespereira wolbachiasignificantlyimpactsthevectorcompetenceofaedesaegyptiformayarovirus AT marcelenevesrocha wolbachiasignificantlyimpactsthevectorcompetenceofaedesaegyptiformayarovirus AT pedrohenriqueferreirasucupira wolbachiasignificantlyimpactsthevectorcompetenceofaedesaegyptiformayarovirus AT fabianoduartecarvalho wolbachiasignificantlyimpactsthevectorcompetenceofaedesaegyptiformayarovirus AT lucianoandrademoreira wolbachiasignificantlyimpactsthevectorcompetenceofaedesaegyptiformayarovirus
_version_	1718394106002014208

Wolbachia significantly impacts the vector competence of Aedes aegypti for Mayaro virus

Ejemplares similares