Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.

Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients. We undertook between June and September 2006 a retrospective cohort study aimed at assessing the course of late rheumatic mani...

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Autores principales:	Daouda Sissoko, Denis Malvy, Khaled Ezzedine, Philippe Renault, Frederic Moscetti, Martine Ledrans, Vincent Pierre
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/886f7cfb7113433e8fefcef95c4c527d
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spelling	oai:doaj.org-article:886f7cfb7113433e8fefcef95c4c527d2021-11-25T06:32:57ZPost-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.1935-27271935-273510.1371/journal.pntd.0000389https://doaj.org/article/886f7cfb7113433e8fefcef95c4c527d2009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19274071/pdf/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients. We undertook between June and September 2006 a retrospective cohort study aimed at assessing the course of late rheumatic manifestations and investigating potential risk factors associated with the persistence of these rheumatic manifestations over 15 months. 147 participants (>16 yrs) with laboratory-confirmed CHIKV disease diagnosed between March 1 and June 30, 2005, were identified through a surveillance database and interviewed by telephone. At the 15-month-period evaluation after diagnosis, 84 of 147 participants (57%) self-reported rheumatic symptoms. Of these 84 patients, 53 (63%) reported permanent trouble while 31 (37%) had recurrent symptoms. Age > or=45 years (OR = 3.9, 95% CI 1.7-9.7), severe initial joint pain (OR = 4.8, 95% CI 1.9-12.1), and presence of underlying osteoarthritis comorbidity (OR = 2.9, 95% CI 1.1-7.4) were predictors of nonrecovery. Our findings suggest that long-term CHIKV rheumatic manifestations seem to be a frequent underlying post-epidemic condition. Three independent risk factors that may aid in early recognition of patients with the highest risk of presenting prolonged CHIKV illness were identified. Such findings may be particularly useful in the development of future prevention and care strategies for this emerging virus infection.Daouda SissokoDenis MalvyKhaled EzzedinePhilippe RenaultFrederic MoscettiMartine LedransVincent PierrePublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 3, Iss 3, p e389 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Daouda Sissoko Denis Malvy Khaled Ezzedine Philippe Renault Frederic Moscetti Martine Ledrans Vincent Pierre Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.
description	Although the acute manifestations of Chikungunya virus (CHIKV) illness are well-documented, few data exist about the long-term rheumatic outcomes of CHIKV-infected patients. We undertook between June and September 2006 a retrospective cohort study aimed at assessing the course of late rheumatic manifestations and investigating potential risk factors associated with the persistence of these rheumatic manifestations over 15 months. 147 participants (>16 yrs) with laboratory-confirmed CHIKV disease diagnosed between March 1 and June 30, 2005, were identified through a surveillance database and interviewed by telephone. At the 15-month-period evaluation after diagnosis, 84 of 147 participants (57%) self-reported rheumatic symptoms. Of these 84 patients, 53 (63%) reported permanent trouble while 31 (37%) had recurrent symptoms. Age > or=45 years (OR = 3.9, 95% CI 1.7-9.7), severe initial joint pain (OR = 4.8, 95% CI 1.9-12.1), and presence of underlying osteoarthritis comorbidity (OR = 2.9, 95% CI 1.1-7.4) were predictors of nonrecovery. Our findings suggest that long-term CHIKV rheumatic manifestations seem to be a frequent underlying post-epidemic condition. Three independent risk factors that may aid in early recognition of patients with the highest risk of presenting prolonged CHIKV illness were identified. Such findings may be particularly useful in the development of future prevention and care strategies for this emerging virus infection.
format	article
author	Daouda Sissoko Denis Malvy Khaled Ezzedine Philippe Renault Frederic Moscetti Martine Ledrans Vincent Pierre
author_facet	Daouda Sissoko Denis Malvy Khaled Ezzedine Philippe Renault Frederic Moscetti Martine Ledrans Vincent Pierre
author_sort	Daouda Sissoko
title	Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.
title_short	Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.
title_full	Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.
title_fullStr	Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.
title_full_unstemmed	Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.
title_sort	post-epidemic chikungunya disease on reunion island: course of rheumatic manifestations and associated factors over a 15-month period.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/886f7cfb7113433e8fefcef95c4c527d
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Post-epidemic Chikungunya disease on Reunion Island: course of rheumatic manifestations and associated factors over a 15-month period.

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