The Role of NLRP3 Inflammasome in Lupus Nephritis

Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptor...

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Autores principales:	Camila Barbosa Oliveira, Camilla Albertina Dantas Lima, Gisele Vajgel, Paula Sandrin-Garcia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	inflammasome NLRP3 lupus nephritis systemic lupus erythematosus Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/8874314f8c4444a39e4cbe2f64dfd88f
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spelling	oai:doaj.org-article:8874314f8c4444a39e4cbe2f64dfd88f2021-11-25T17:57:00ZThe Role of NLRP3 Inflammasome in Lupus Nephritis10.3390/ijms2222124761422-00671661-6596https://doaj.org/article/8874314f8c4444a39e4cbe2f64dfd88f2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12476https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the pathogenesis of LN. In this review manuscript, we approach the relation between the NLRP3 inflammasome, SLE, and LN, highlighting the influence of genetic susceptibility of NLRP3 polymorphisms in the disease; the main functional studies using cellular and animal models of NLRP3 activation; and finally, some mechanisms of NLRP3 inhibition for the development of possible therapeutic drugs for LN.Camila Barbosa OliveiraCamilla Albertina Dantas LimaGisele VajgelPaula Sandrin-GarciaMDPI AGarticleinflammasomeNLRP3lupus nephritissystemic lupus erythematosusBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12476, p 12476 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammasome NLRP3 lupus nephritis systemic lupus erythematosus Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	inflammasome NLRP3 lupus nephritis systemic lupus erythematosus Biology (General) QH301-705.5 Chemistry QD1-999 Camila Barbosa Oliveira Camilla Albertina Dantas Lima Gisele Vajgel Paula Sandrin-Garcia The Role of NLRP3 Inflammasome in Lupus Nephritis
description	Lupus nephritis (LN) is the most frequent and severe of systemic lupus erythematosus (SLE) clinical manifestations and contributes to the increase of morbidity and mortality of patients due to chronic kidney disease. The NLRP3 (NLR pyrin domain containing 3) is a member of the NLR (NOD-like receptors), and its activation results in the production of pro-inflammatory cytokines, which can contribute to the pathogenesis of LN. In this review manuscript, we approach the relation between the NLRP3 inflammasome, SLE, and LN, highlighting the influence of genetic susceptibility of NLRP3 polymorphisms in the disease; the main functional studies using cellular and animal models of NLRP3 activation; and finally, some mechanisms of NLRP3 inhibition for the development of possible therapeutic drugs for LN.
format	article
author	Camila Barbosa Oliveira Camilla Albertina Dantas Lima Gisele Vajgel Paula Sandrin-Garcia
author_facet	Camila Barbosa Oliveira Camilla Albertina Dantas Lima Gisele Vajgel Paula Sandrin-Garcia
author_sort	Camila Barbosa Oliveira
title	The Role of NLRP3 Inflammasome in Lupus Nephritis
title_short	The Role of NLRP3 Inflammasome in Lupus Nephritis
title_full	The Role of NLRP3 Inflammasome in Lupus Nephritis
title_fullStr	The Role of NLRP3 Inflammasome in Lupus Nephritis
title_full_unstemmed	The Role of NLRP3 Inflammasome in Lupus Nephritis
title_sort	role of nlrp3 inflammasome in lupus nephritis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8874314f8c4444a39e4cbe2f64dfd88f
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The Role of NLRP3 Inflammasome in Lupus Nephritis

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