Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis

Abstract To date, it is unclear which treatment modality, liver resection (LR) or transarterial chemoembolization (TACE) is the more appropriate for patients with huge (≥ 10 cm) hepatocellular carcinoma (HCC). The study aim was to compare, using propensity score matching, short- and long-term outcom...

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Autores principales:	A. Bogdanovic, P. Bulajic, D. Masulovic, N. Bidzic, M. Zivanovic, D. Galun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88743c5676b84e14b3d5aa1b295cdd24
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spelling	oai:doaj.org-article:88743c5676b84e14b3d5aa1b295cdd242021-12-02T13:20:21ZLiver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis10.1038/s41598-021-83868-92045-2322https://doaj.org/article/88743c5676b84e14b3d5aa1b295cdd242021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83868-9https://doaj.org/toc/2045-2322Abstract To date, it is unclear which treatment modality, liver resection (LR) or transarterial chemoembolization (TACE) is the more appropriate for patients with huge (≥ 10 cm) hepatocellular carcinoma (HCC). The study aim was to compare, using propensity score matching, short- and long-term outcomes of patients with huge HCC who underwent potentially curative LR or TACE. Patients with huge HCC who had been managed at the Clinical Center by curative-intent LR or by palliative TACE between November 2001 and December 2018 were retrospectively identified. The morbidity and mortality rates and overall survival were compared between the groups before and after the propensity score matching. Independent predictors of long-term survival were determined by multivariate analysis. A total of 103 patients with huge HCC were included; 68 were assigned to the LR group and 35 to the TACE group. The overall morbidity rate was higher in the LR group than in the TACE group before matching (64.7% vs. 37.1%, p = 0.012), while there was no difference after matching (60% vs. 30%, p = 0.055). The major morbidity and 30-days mortality were similar between the groups before and after matching. The LR group was associated with longer overall survival than the TACE group before matching (p = 0.032) and after matching (p = 0.023). Total bilirubin and TACE treatment were independent prognostic factors associated with long-term survival. In patients with huge HCC, liver resection provides better long-term survival than TACE and should be considered as the initial treatment whenever possible.A. BogdanovicP. BulajicD. MasulovicN. BidzicM. ZivanovicD. GalunNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q A. Bogdanovic P. Bulajic D. Masulovic N. Bidzic M. Zivanovic D. Galun Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
description	Abstract To date, it is unclear which treatment modality, liver resection (LR) or transarterial chemoembolization (TACE) is the more appropriate for patients with huge (≥ 10 cm) hepatocellular carcinoma (HCC). The study aim was to compare, using propensity score matching, short- and long-term outcomes of patients with huge HCC who underwent potentially curative LR or TACE. Patients with huge HCC who had been managed at the Clinical Center by curative-intent LR or by palliative TACE between November 2001 and December 2018 were retrospectively identified. The morbidity and mortality rates and overall survival were compared between the groups before and after the propensity score matching. Independent predictors of long-term survival were determined by multivariate analysis. A total of 103 patients with huge HCC were included; 68 were assigned to the LR group and 35 to the TACE group. The overall morbidity rate was higher in the LR group than in the TACE group before matching (64.7% vs. 37.1%, p = 0.012), while there was no difference after matching (60% vs. 30%, p = 0.055). The major morbidity and 30-days mortality were similar between the groups before and after matching. The LR group was associated with longer overall survival than the TACE group before matching (p = 0.032) and after matching (p = 0.023). Total bilirubin and TACE treatment were independent prognostic factors associated with long-term survival. In patients with huge HCC, liver resection provides better long-term survival than TACE and should be considered as the initial treatment whenever possible.
format	article
author	A. Bogdanovic P. Bulajic D. Masulovic N. Bidzic M. Zivanovic D. Galun
author_facet	A. Bogdanovic P. Bulajic D. Masulovic N. Bidzic M. Zivanovic D. Galun
author_sort	A. Bogdanovic
title	Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
title_short	Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
title_full	Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
title_fullStr	Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
title_full_unstemmed	Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
title_sort	liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88743c5676b84e14b3d5aa1b295cdd24
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Liver resection versus transarterial chemoembolization for huge hepatocellular carcinoma: a propensity score matched analysis

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