Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand
Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation.
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Nature Portfolio
2017
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oai:doaj.org-article:88765518aaa04e1c8dca48de84763ef52021-12-02T14:40:58ZCrystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand10.1038/ncomms153832041-1723https://doaj.org/article/88765518aaa04e1c8dca48de84763ef52017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15383https://doaj.org/toc/2041-1723Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation.Xianjun ZhangFei ZhaoYiran WuJun YangGye Won HanSuwen ZhaoAndrii IshchenkoLintao YeXi LinKang DingVenkatasubramanian DharmarajanPatrick R. GriffinCornelius GatiGarrett NelsonMark S. HunterMichael A. HansonVadim CherezovRaymond C. StevensWenfu TanHouchao TaoFei XuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Xianjun Zhang Fei Zhao Yiran Wu Jun Yang Gye Won Han Suwen Zhao Andrii Ishchenko Lintao Ye Xi Lin Kang Ding Venkatasubramanian Dharmarajan Patrick R. Griffin Cornelius Gati Garrett Nelson Mark S. Hunter Michael A. Hanson Vadim Cherezov Raymond C. Stevens Wenfu Tan Houchao Tao Fei Xu Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| description |
Smoothened receptors (SMO) play a key role in the Hedgehog signalling pathway. Here the authors present the structure of a multi-domain human SMO with a rationally designed stabilizing ligand bound in the transmembrane domain of the receptor, and propose a model for SMO activation. |
| format |
article |
| author |
Xianjun Zhang Fei Zhao Yiran Wu Jun Yang Gye Won Han Suwen Zhao Andrii Ishchenko Lintao Ye Xi Lin Kang Ding Venkatasubramanian Dharmarajan Patrick R. Griffin Cornelius Gati Garrett Nelson Mark S. Hunter Michael A. Hanson Vadim Cherezov Raymond C. Stevens Wenfu Tan Houchao Tao Fei Xu |
| author_facet |
Xianjun Zhang Fei Zhao Yiran Wu Jun Yang Gye Won Han Suwen Zhao Andrii Ishchenko Lintao Ye Xi Lin Kang Ding Venkatasubramanian Dharmarajan Patrick R. Griffin Cornelius Gati Garrett Nelson Mark S. Hunter Michael A. Hanson Vadim Cherezov Raymond C. Stevens Wenfu Tan Houchao Tao Fei Xu |
| author_sort |
Xianjun Zhang |
| title |
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| title_short |
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| title_full |
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| title_fullStr |
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| title_full_unstemmed |
Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| title_sort |
crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/88765518aaa04e1c8dca48de84763ef5 |
| work_keys_str_mv |
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