Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation

Shigeru Maeda1, Ichiro Nakatsuka1, Yukiko Hayashi1, Hitoshi Higuchi1, Masahiko Shimada2, Takuya Miyawaki11Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan; 2Orofacial Pain Management, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University...

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Autores principales:	Shigeru Maeda, Ichiro Nakatsuka, Yukiko Hayashi, Hitoshi Higuchi, Masahiko Shimada, Takuya Miyawaki
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2008
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8879e3c8f7bb4912aa16640c8188a8c0
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spelling	oai:doaj.org-article:8879e3c8f7bb4912aa16640c8188a8c02021-12-02T08:28:10ZHeme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation1176-63281178-2021https://doaj.org/article/8879e3c8f7bb4912aa16640c8188a8c02008-06-01T00:00:00Zhttp://www.dovepress.com/heme-oxygenase-1-induction-in-the-brain-during-lipopolysaccharide-indu-a1876https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Shigeru Maeda1, Ichiro Nakatsuka1, Yukiko Hayashi1, Hitoshi Higuchi1, Masahiko Shimada2, Takuya Miyawaki11Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan; 2Orofacial Pain Management, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Delirium occurs in 23% of sepsis patients, in which pro-inflammatory cytokines and nitric oxide are suggested to be involved. However, in animal experiments, even a subseptic dose of lipopolysaccharide (LPS) injection induces both pro-inflammatory cytokines and inducible nitric oxide synthase in the brain, suggesting that the brain oxidative reaction can be induced in the subseptic condition. Then, we evaluated the changes of heme oxygenase-1 (HO-1), a sensitive oxidative marker, as well as interleukin (IL)-1&beta;, IL-6, and inductible nitric oxide synthase (iNOS) mRNA in the hypothalamus and hippocampus of rats using real-time PCR after peripheral injection of LPS (2.0 mg/kg). As a result, these four kinds of mRNAs were induced significantly in both areas after LPS injection. These results suggest that peripheral inflammation induces an oxidative reaction in the brain, even if the inflammation is not lethal. It is also considered that several pathways are involved in brain HO-1 induction.Keywords: heme oxygenase-1, interleukin-1&beta;, interleukin-6, lipopolysaccharide, hypothalamus, hippocampus Shigeru MaedaIchiro NakatsukaYukiko HayashiHitoshi HiguchiMasahiko ShimadaTakuya MiyawakiDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2008, Iss Issue 3, Pp 663-667 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shigeru Maeda Ichiro Nakatsuka Yukiko Hayashi Hitoshi Higuchi Masahiko Shimada Takuya Miyawaki Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
description	Shigeru Maeda1, Ichiro Nakatsuka1, Yukiko Hayashi1, Hitoshi Higuchi1, Masahiko Shimada2, Takuya Miyawaki11Department of Dental Anesthesiology, Okayama University Hospital, Okayama, Japan; 2Orofacial Pain Management, Department of Oral Restitution, Graduate School, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Delirium occurs in 23% of sepsis patients, in which pro-inflammatory cytokines and nitric oxide are suggested to be involved. However, in animal experiments, even a subseptic dose of lipopolysaccharide (LPS) injection induces both pro-inflammatory cytokines and inducible nitric oxide synthase in the brain, suggesting that the brain oxidative reaction can be induced in the subseptic condition. Then, we evaluated the changes of heme oxygenase-1 (HO-1), a sensitive oxidative marker, as well as interleukin (IL)-1&beta;, IL-6, and inductible nitric oxide synthase (iNOS) mRNA in the hypothalamus and hippocampus of rats using real-time PCR after peripheral injection of LPS (2.0 mg/kg). As a result, these four kinds of mRNAs were induced significantly in both areas after LPS injection. These results suggest that peripheral inflammation induces an oxidative reaction in the brain, even if the inflammation is not lethal. It is also considered that several pathways are involved in brain HO-1 induction.Keywords: heme oxygenase-1, interleukin-1&beta;, interleukin-6, lipopolysaccharide, hypothalamus, hippocampus
format	article
author	Shigeru Maeda Ichiro Nakatsuka Yukiko Hayashi Hitoshi Higuchi Masahiko Shimada Takuya Miyawaki
author_facet	Shigeru Maeda Ichiro Nakatsuka Yukiko Hayashi Hitoshi Higuchi Masahiko Shimada Takuya Miyawaki
author_sort	Shigeru Maeda
title	Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
title_short	Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
title_full	Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
title_fullStr	Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
title_full_unstemmed	Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
title_sort	heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation
publisher	Dove Medical Press
publishDate	2008
url	https://doaj.org/article/8879e3c8f7bb4912aa16640c8188a8c0
work_keys_str_mv	AT shigerumaeda hemeoxygenase1inductioninthebrainduringlipopolysaccharideinducedacuteinflammation AT ichironakatsuka hemeoxygenase1inductioninthebrainduringlipopolysaccharideinducedacuteinflammation AT yukikohayashi hemeoxygenase1inductioninthebrainduringlipopolysaccharideinducedacuteinflammation AT hitoshihiguchi hemeoxygenase1inductioninthebrainduringlipopolysaccharideinducedacuteinflammation AT masahikoshimada hemeoxygenase1inductioninthebrainduringlipopolysaccharideinducedacuteinflammation AT takuyamiyawaki hemeoxygenase1inductioninthebrainduringlipopolysaccharideinducedacuteinflammation
_version_	1718398498133508096

Heme oxygenase-1 induction in the brain during lipopolysaccharide-induced acute inflammation

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