Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors

Schädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffold...

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Autores principales:	Gian Nutal Schädli, Jolanda R. Vetsch, Robert P. Baumann, Anke M. de Leeuw, Esther Wehrle, Marina Rubert, Ralph Müller
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/887e194078584a6e9ab137b67f229d0e
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spelling	oai:doaj.org-article:887e194078584a6e9ab137b67f229d0e2021-12-02T13:24:17ZTime-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors10.1038/s42003-020-01635-42399-3642https://doaj.org/article/887e194078584a6e9ab137b67f229d0e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s42003-020-01635-4https://doaj.org/toc/2399-3642Schädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffolds performance in vitro and might reduce the use of animals for experimentation.Gian Nutal SchädliJolanda R. VetschRobert P. BaumannAnke M. de LeeuwEsther WehrleMarina RubertRalph MüllerNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Gian Nutal Schädli Jolanda R. Vetsch Robert P. Baumann Anke M. de Leeuw Esther Wehrle Marina Rubert Ralph Müller Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
description	Schädli et al. present a bioreactor system that combines mechanical loading with longitudinal microCT imaging to assess bone mineralization in a poly(lactic-co-glycolic acid) (PLGA) scaffold reinforced with nanoparticles. This approach allows rapid and rigorous evaluation of engineered bone scaffolds performance in vitro and might reduce the use of animals for experimentation.
format	article
author	Gian Nutal Schädli Jolanda R. Vetsch Robert P. Baumann Anke M. de Leeuw Esther Wehrle Marina Rubert Ralph Müller
author_facet	Gian Nutal Schädli Jolanda R. Vetsch Robert P. Baumann Anke M. de Leeuw Esther Wehrle Marina Rubert Ralph Müller
author_sort	Gian Nutal Schädli
title	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_short	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_full	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_fullStr	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_full_unstemmed	Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
title_sort	time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/887e194078584a6e9ab137b67f229d0e
work_keys_str_mv	AT giannutalschadli timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors AT jolandarvetsch timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors AT robertpbaumann timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors AT ankemdeleeuw timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors AT estherwehrle timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors AT marinarubert timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors AT ralphmuller timelapsedimagingofnanocompositescaffoldsrevealsincreasedboneformationindynamiccompressionbioreactors
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Time-lapsed imaging of nanocomposite scaffolds reveals increased bone formation in dynamic compression bioreactors

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