Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Inflammatory monocytes regulate Th1 oriented immunity to CpG adjuvanted protein vaccines through production of IL-12

Abstract Due to their capacity to skew T cell responses towards Th1 oriented immunity, oligonucleotides containing unmethylated CpG motifs (CpG) have emerged as interesting adjuvants for vaccination. Whereas the signalling pathways in response to CpG mediated TLR9 activation have been extensively do...

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Autores principales: S. De Koker, L. Van Hoecke, A. De Beuckelaer, K. Roose, K. Deswarte, M. A. Willart, P. Bogaert, T. Naessens, B. G. De Geest, X. Saelens, B. N. Lambrecht, J. Grooten
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/88807313776544b8b57f2db47992b929
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