A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage

Abstract Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus...

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Autores principales:	Humaira Sadaf, Virendra R. Desai, Vivek Misra, Eugene Golanov, Muralidhar L. Hegde, Sonia Villapol, Christof Karmonik, Angelique Regnier‐Golanov, Dimitri Sayenko, Philip J. Horner, Robert Krencik, Yi Lan Weng, Farhaan S. Vahidy, Gavin W. Britz
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/88832c0f50434bdb95bd8cdeed490c98
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spelling	oai:doaj.org-article:88832c0f50434bdb95bd8cdeed490c982021-11-22T11:11:53ZA contemporary review of therapeutic and regenerative management of intracerebral hemorrhage2328-950310.1002/acn3.51443https://doaj.org/article/88832c0f50434bdb95bd8cdeed490c982021-11-01T00:00:00Zhttps://doi.org/10.1002/acn3.51443https://doaj.org/toc/2328-9503Abstract Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus include the management of blood pressure, intracranial pressure, coagulopathy, and intraventricular hemorrhage, as well as the role of surgery, regeneration, rehabilitation, and secondary prevention. Results of various phase II and III trials are incorporated. In summary, ICH patients should undergo rapid evaluation with neuroimaging, and early interventions should include systolic blood pressure control in the range of 140 mmHg, correction of coagulopathy if indicated, and assessment for surgical intervention. ICH patients should be managed in dedicated neurosurgical intensive care or stroke units where continuous monitoring of neurological status and evaluation for neurological deterioration is rapidly possible. Extravasation of hematoma may be helpful in patients with intraventricular extension of ICH. The goal of care is to reduce mortality and enable multimodal rehabilitative therapy.Humaira SadafVirendra R. DesaiVivek MisraEugene GolanovMuralidhar L. HegdeSonia VillapolChristof KarmonikAngelique Regnier‐GolanovDimitri SayenkoPhilip J. HornerRobert KrencikYi Lan WengFarhaan S. VahidyGavin W. BritzWileyarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENAnnals of Clinical and Translational Neurology, Vol 8, Iss 11, Pp 2211-2221 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Humaira Sadaf Virendra R. Desai Vivek Misra Eugene Golanov Muralidhar L. Hegde Sonia Villapol Christof Karmonik Angelique Regnier‐Golanov Dimitri Sayenko Philip J. Horner Robert Krencik Yi Lan Weng Farhaan S. Vahidy Gavin W. Britz A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
description	Abstract Intracerebral hemorrhage (ICH) remains a common and debilitating form of stroke. This neurological emergency must be diagnosed and treated rapidly yet effectively. In this article, we review the medical, surgical, repair, and regenerative treatment options for managing ICH. Topics of focus include the management of blood pressure, intracranial pressure, coagulopathy, and intraventricular hemorrhage, as well as the role of surgery, regeneration, rehabilitation, and secondary prevention. Results of various phase II and III trials are incorporated. In summary, ICH patients should undergo rapid evaluation with neuroimaging, and early interventions should include systolic blood pressure control in the range of 140 mmHg, correction of coagulopathy if indicated, and assessment for surgical intervention. ICH patients should be managed in dedicated neurosurgical intensive care or stroke units where continuous monitoring of neurological status and evaluation for neurological deterioration is rapidly possible. Extravasation of hematoma may be helpful in patients with intraventricular extension of ICH. The goal of care is to reduce mortality and enable multimodal rehabilitative therapy.
format	article
author	Humaira Sadaf Virendra R. Desai Vivek Misra Eugene Golanov Muralidhar L. Hegde Sonia Villapol Christof Karmonik Angelique Regnier‐Golanov Dimitri Sayenko Philip J. Horner Robert Krencik Yi Lan Weng Farhaan S. Vahidy Gavin W. Britz
author_facet	Humaira Sadaf Virendra R. Desai Vivek Misra Eugene Golanov Muralidhar L. Hegde Sonia Villapol Christof Karmonik Angelique Regnier‐Golanov Dimitri Sayenko Philip J. Horner Robert Krencik Yi Lan Weng Farhaan S. Vahidy Gavin W. Britz
author_sort	Humaira Sadaf
title	A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
title_short	A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
title_full	A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
title_fullStr	A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
title_full_unstemmed	A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
title_sort	contemporary review of therapeutic and regenerative management of intracerebral hemorrhage
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/88832c0f50434bdb95bd8cdeed490c98
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A contemporary review of therapeutic and regenerative management of intracerebral hemorrhage

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