Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell function and intra-islet connectivity.

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Autores principales:	Elina Akalestou, Kinga Suba, Livia Lopez-Noriega, Eleni Georgiadou, Pauline Chabosseau, Alasdair Gallie, Asger Wretlind, Cristina Quigley, Isabelle Leclerc, Victoria Salem, Guy A. Rutter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e
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spelling	oai:doaj.org-article:8883f2819a32466d8fcddbfc90b52f1e2021-12-02T15:09:10ZIntravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice10.1038/s41467-021-25423-82041-1723https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25423-8https://doaj.org/toc/2041-1723Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell function and intra-islet connectivity.Elina AkalestouKinga SubaLivia Lopez-NoriegaEleni GeorgiadouPauline ChabosseauAlasdair GallieAsger WretlindCristina QuigleyIsabelle LeclercVictoria SalemGuy A. RutterNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elina Akalestou Kinga Suba Livia Lopez-Noriega Eleni Georgiadou Pauline Chabosseau Alasdair Gallie Asger Wretlind Cristina Quigley Isabelle Leclerc Victoria Salem Guy A. Rutter Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
description	Bariatric surgery procedures reduce weight and improve metabolic diseases. Here the authors investigate the effects of Vertical Sleeve Gastrectomy (VSG) on beta-cell function in mice using in vivo Ca2 + imaging and show that VSG increases beta-cell function and intra-islet connectivity.
format	article
author	Elina Akalestou Kinga Suba Livia Lopez-Noriega Eleni Georgiadou Pauline Chabosseau Alasdair Gallie Asger Wretlind Cristina Quigley Isabelle Leclerc Victoria Salem Guy A. Rutter
author_facet	Elina Akalestou Kinga Suba Livia Lopez-Noriega Eleni Georgiadou Pauline Chabosseau Alasdair Gallie Asger Wretlind Cristina Quigley Isabelle Leclerc Victoria Salem Guy A. Rutter
author_sort	Elina Akalestou
title	Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
title_short	Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
title_full	Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
title_fullStr	Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
title_full_unstemmed	Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
title_sort	intravital imaging of islet ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8883f2819a32466d8fcddbfc90b52f1e
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Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

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