Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis

Abstract Patients with ulcerative colitis (UC) have an altered gut microbiota composition, but the microbial relationship to disease activity needs to be further elucidated. Therefore, temporal dynamics of the fecal microbial community during remission and flare was determined. Fecal samples were co...

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Autores principales:	Lena Öhman, Anders Lasson, Anna Strömbeck, Stefan Isaksson, Marcus Hesselmar, Magnus Simrén, Hans Strid, Maria K. Magnusson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/888e6863e5fa45338bf1f85f53a2768b
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spelling	oai:doaj.org-article:888e6863e5fa45338bf1f85f53a2768b2021-12-02T13:39:34ZFecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis10.1038/s41598-021-87973-72045-2322https://doaj.org/article/888e6863e5fa45338bf1f85f53a2768b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87973-7https://doaj.org/toc/2045-2322Abstract Patients with ulcerative colitis (UC) have an altered gut microbiota composition, but the microbial relationship to disease activity needs to be further elucidated. Therefore, temporal dynamics of the fecal microbial community during remission and flare was determined. Fecal samples were collected at 2–6 time-points from UC patients during established disease (cohort EST) and at diagnosis (cohort NEW). Sampling range for cohort EST was 3–10 months and for cohort NEW 36 months. Relapses were monitored for an additional three years for cohort EST. Microbial composition was assessed by Genetic Analysis GA-map Dysbiosis Test, targeting ≥ 300 bacteria. Eighteen patients in cohort EST (8 with maintained remission and 10 experiencing a flare), provided 71 fecal samples. In cohort NEW, 13 patients provided 49 fecal samples. The microbial composition showed no clustering related to disease activity in any cohort. Microbial dissimilarity was higher between than within patients for both cohorts, irrespective of presence of a flare. Microbial stability within patients was constant over time with no major shift in overall composition nor modification in the abundance of any specific species. Microbial composition was not affected by intensified medical treatment or linked to future disease course. Thus in UC, the gut microbiota is highly stable irrespective of disease stage, disease activity or treatment escalation. This suggests that prolonged dietary interventions or repeated fecal transplantations are needed to be able to induce permanent alterations of the gut microbiota.Lena ÖhmanAnders LassonAnna StrömbeckStefan IsakssonMarcus HesselmarMagnus SimrénHans StridMaria K. MagnussonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lena Öhman Anders Lasson Anna Strömbeck Stefan Isaksson Marcus Hesselmar Magnus Simrén Hans Strid Maria K. Magnusson Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
description	Abstract Patients with ulcerative colitis (UC) have an altered gut microbiota composition, but the microbial relationship to disease activity needs to be further elucidated. Therefore, temporal dynamics of the fecal microbial community during remission and flare was determined. Fecal samples were collected at 2–6 time-points from UC patients during established disease (cohort EST) and at diagnosis (cohort NEW). Sampling range for cohort EST was 3–10 months and for cohort NEW 36 months. Relapses were monitored for an additional three years for cohort EST. Microbial composition was assessed by Genetic Analysis GA-map Dysbiosis Test, targeting ≥ 300 bacteria. Eighteen patients in cohort EST (8 with maintained remission and 10 experiencing a flare), provided 71 fecal samples. In cohort NEW, 13 patients provided 49 fecal samples. The microbial composition showed no clustering related to disease activity in any cohort. Microbial dissimilarity was higher between than within patients for both cohorts, irrespective of presence of a flare. Microbial stability within patients was constant over time with no major shift in overall composition nor modification in the abundance of any specific species. Microbial composition was not affected by intensified medical treatment or linked to future disease course. Thus in UC, the gut microbiota is highly stable irrespective of disease stage, disease activity or treatment escalation. This suggests that prolonged dietary interventions or repeated fecal transplantations are needed to be able to induce permanent alterations of the gut microbiota.
format	article
author	Lena Öhman Anders Lasson Anna Strömbeck Stefan Isaksson Marcus Hesselmar Magnus Simrén Hans Strid Maria K. Magnusson
author_facet	Lena Öhman Anders Lasson Anna Strömbeck Stefan Isaksson Marcus Hesselmar Magnus Simrén Hans Strid Maria K. Magnusson
author_sort	Lena Öhman
title	Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
title_short	Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
title_full	Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
title_fullStr	Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
title_full_unstemmed	Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
title_sort	fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/888e6863e5fa45338bf1f85f53a2768b
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Fecal microbiota dynamics during disease activity and remission in newly diagnosed and established ulcerative colitis

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