Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its deglutarylation and functional activation.

Guardado en:

Detalles Bibliográficos
Autores principales:	Yun-Qian Wang, Hao-Lian Wang, Jie Xu, Juan Tan, Lin-Na Fu, Ji-Lin Wang, Tian-Hui Zou, Dan-Feng Sun, Qin-Yan Gao, Ying-Xuan Chen, Jing-Yuan Fang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8890027318944e53acbc90ea70f0641b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8890027318944e53acbc90ea70f0641b
record_format	dspace
spelling	oai:doaj.org-article:8890027318944e53acbc90ea70f0641b2021-12-02T17:33:00ZSirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner10.1038/s41467-018-02951-42041-1723https://doaj.org/article/8890027318944e53acbc90ea70f0641b2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-02951-4https://doaj.org/toc/2041-1723Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its deglutarylation and functional activation.Yun-Qian WangHao-Lian WangJie XuJuan TanLin-Na FuJi-Lin WangTian-Hui ZouDan-Feng SunQin-Yan GaoYing-Xuan ChenJing-Yuan FangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yun-Qian Wang Hao-Lian Wang Jie Xu Juan Tan Lin-Na Fu Ji-Lin Wang Tian-Hui Zou Dan-Feng Sun Qin-Yan Gao Ying-Xuan Chen Jing-Yuan Fang Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
description	Tumour metabolism can be controlled through post-translational modifications. Here the authors show that Sirtuin5 promotes glutaminolysis in colorectal cancer cells via glutamate dehydrogenase-1, a critical regulator of glutaminolysis, inducing its deglutarylation and functional activation.
format	article
author	Yun-Qian Wang Hao-Lian Wang Jie Xu Juan Tan Lin-Na Fu Ji-Lin Wang Tian-Hui Zou Dan-Feng Sun Qin-Yan Gao Ying-Xuan Chen Jing-Yuan Fang
author_facet	Yun-Qian Wang Hao-Lian Wang Jie Xu Juan Tan Lin-Na Fu Ji-Lin Wang Tian-Hui Zou Dan-Feng Sun Qin-Yan Gao Ying-Xuan Chen Jing-Yuan Fang
author_sort	Yun-Qian Wang
title	Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
title_short	Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
title_full	Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
title_fullStr	Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
title_full_unstemmed	Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
title_sort	sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/8890027318944e53acbc90ea70f0641b
work_keys_str_mv	AT yunqianwang sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT haolianwang sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT jiexu sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT juantan sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT linnafu sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT jilinwang sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT tianhuizou sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT danfengsun sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT qinyangao sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT yingxuanchen sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner AT jingyuanfang sirtuin5contributestocolorectalcarcinogenesisbyenhancingglutaminolysisinadeglutarylationdependentmanner
_version_	1718380072258240512

Sirtuin5 contributes to colorectal carcinogenesis by enhancing glutaminolysis in a deglutarylation-dependent manner

Ejemplares similares