GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT

In the present study, we have investigated frequency of genotypes and functional alleles of genes encoding chemokines (CXCL12 rs1801157, CCL2 rs1024611), chemokine receptors (CCR5 del32, CX3CR1 rs3732378), acute phase proteins SAA rs1136743, and CD14 rs2569190 polymorphisms among Tatar obese or over...

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Autores principales:	O. V. Kochetova, L. Z. Akhmadishina, G. F. Korytina, Т. V. Victorova
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2018
Materias:	obesity, genetic markers, chemokines, chemokine receptors, inflammation Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/8892f359b488490c9c9a03392285ec01
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spelling	oai:doaj.org-article:8892f359b488490c9c9a03392285ec012021-11-18T08:03:47ZGENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT1563-06252313-741X10.15789/1563-0625-2018-5-739-746https://doaj.org/article/8892f359b488490c9c9a03392285ec012018-11-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1642https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XIn the present study, we have investigated frequency of genotypes and functional alleles of genes encoding chemokines (CXCL12 rs1801157, CCL2 rs1024611), chemokine receptors (CCR5 del32, CX3CR1 rs3732378), acute phase proteins SAA rs1136743, and CD14 rs2569190 polymorphisms among Tatar obese or overweight women from the Republic of Bashkortostan.The group of patients comprised unrelated women with obesity (BMI ≥ 30 kg/m2, n = 225), females with overweight (BMI 25.0-29.9 kg/m2, n = 184), and control group of women (n = 327) BMI < 25.0 kg/m2. Genotyping was performed by PCR-RFLP analysis. Patients and controls differed in such parameters as body weight (p = 0.00001), BMI level (p = 0.001) and fasting glucose level (p = 0.0001).An association was revealed between obesity and AG-AA genotypes (p = 0.007) and A allele (p = 0.003) of polymorphic locus rs3732378 of CXCR1 gene, as well as TT genotype (p = 0.027) and T allele (p = 0.021) of polymorphic locus rs1136743 of SAA gene. It has been shown that the AA genotype of polymorphic locus rs3732378 of the CX3CR1 gene is associated with increased body weight (p = 0.002) and elevated BMI (p = 0.018); the GG genotype of polymorphic locus rs1024611 of the CCL2 gene is associated with elevated fasting glucose level (p = 0.001).As based on clinical and genetic data and using logistic regression, some statistically significant differences were revealed, which allow to predict development of obesity in Tatar women.O. V. KochetovaL. Z. AkhmadishinaG. F. KorytinaТ. V. VictorovaSPb RAACIarticleobesity, genetic markers, chemokines, chemokine receptors, inflammationImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 20, Iss 5, Pp 739-746 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	obesity, genetic markers, chemokines, chemokine receptors, inflammation Immunologic diseases. Allergy RC581-607
spellingShingle	obesity, genetic markers, chemokines, chemokine receptors, inflammation Immunologic diseases. Allergy RC581-607 O. V. Kochetova L. Z. Akhmadishina G. F. Korytina Т. V. Victorova GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT
description	In the present study, we have investigated frequency of genotypes and functional alleles of genes encoding chemokines (CXCL12 rs1801157, CCL2 rs1024611), chemokine receptors (CCR5 del32, CX3CR1 rs3732378), acute phase proteins SAA rs1136743, and CD14 rs2569190 polymorphisms among Tatar obese or overweight women from the Republic of Bashkortostan.The group of patients comprised unrelated women with obesity (BMI ≥ 30 kg/m2, n = 225), females with overweight (BMI 25.0-29.9 kg/m2, n = 184), and control group of women (n = 327) BMI < 25.0 kg/m2. Genotyping was performed by PCR-RFLP analysis. Patients and controls differed in such parameters as body weight (p = 0.00001), BMI level (p = 0.001) and fasting glucose level (p = 0.0001).An association was revealed between obesity and AG-AA genotypes (p = 0.007) and A allele (p = 0.003) of polymorphic locus rs3732378 of CXCR1 gene, as well as TT genotype (p = 0.027) and T allele (p = 0.021) of polymorphic locus rs1136743 of SAA gene. It has been shown that the AA genotype of polymorphic locus rs3732378 of the CX3CR1 gene is associated with increased body weight (p = 0.002) and elevated BMI (p = 0.018); the GG genotype of polymorphic locus rs1024611 of the CCL2 gene is associated with elevated fasting glucose level (p = 0.001).As based on clinical and genetic data and using logistic regression, some statistically significant differences were revealed, which allow to predict development of obesity in Tatar women.
format	article
author	O. V. Kochetova L. Z. Akhmadishina G. F. Korytina Т. V. Victorova
author_facet	O. V. Kochetova L. Z. Akhmadishina G. F. Korytina Т. V. Victorova
author_sort	O. V. Kochetova
title	GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT
title_short	GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT
title_full	GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT
title_fullStr	GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT
title_full_unstemmed	GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT
title_sort	gene polymorphism analysis of chemokines, chemokine receptors, acute phase proteins, and cd14 in female obesity development
publisher	SPb RAACI
publishDate	2018
url	https://doaj.org/article/8892f359b488490c9c9a03392285ec01
work_keys_str_mv	AT ovkochetova genepolymorphismanalysisofchemokineschemokinereceptorsacutephaseproteinsandcd14infemaleobesitydevelopment AT lzakhmadishina genepolymorphismanalysisofchemokineschemokinereceptorsacutephaseproteinsandcd14infemaleobesitydevelopment AT gfkorytina genepolymorphismanalysisofchemokineschemokinereceptorsacutephaseproteinsandcd14infemaleobesitydevelopment AT tvvictorova genepolymorphismanalysisofchemokineschemokinereceptorsacutephaseproteinsandcd14infemaleobesitydevelopment
_version_	1718422363793522688

GENE POLYMORPHISM ANALYSIS OF CHEMOKINES, CHEMOKINE RECEPTORS, ACUTE PHASE PROTEINS, AND CD14 IN FEMALE OBESITY DEVELOPMENT

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