Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

Activation of Toll-like receptor (TLR) is generally associated with increased immune activity. Here, the authors show, using syngeneic mouse models, that combined deficiency of TLR 3/7/9 in the host induces an inflamed tumour phenotype and results in T cell dependent tumour regression after an initi...

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Autores principales:	Johanna C. Klein, Katrin Moses, Gennadiy Zelinskyy, Simon Sody, Jan Buer, Stephan Lang, Iris Helfrich, Ulf Dittmer, Carsten J. Kirschning, Sven Brandau
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88984c6e0d5c4a3888ff0fc853eecb82
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spelling	oai:doaj.org-article:88984c6e0d5c4a3888ff0fc853eecb822021-12-02T14:40:57ZCombined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth10.1038/ncomms146002041-1723https://doaj.org/article/88984c6e0d5c4a3888ff0fc853eecb822017-03-01T00:00:00Zhttps://doi.org/10.1038/ncomms14600https://doaj.org/toc/2041-1723Activation of Toll-like receptor (TLR) is generally associated with increased immune activity. Here, the authors show, using syngeneic mouse models, that combined deficiency of TLR 3/7/9 in the host induces an inflamed tumour phenotype and results in T cell dependent tumour regression after an initial growth.Johanna C. KleinKatrin MosesGennadiy ZelinskyySimon SodyJan BuerStephan LangIris HelfrichUlf DittmerCarsten J. KirschningSven BrandauNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Johanna C. Klein Katrin Moses Gennadiy Zelinskyy Simon Sody Jan Buer Stephan Lang Iris Helfrich Ulf Dittmer Carsten J. Kirschning Sven Brandau Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
description	Activation of Toll-like receptor (TLR) is generally associated with increased immune activity. Here, the authors show, using syngeneic mouse models, that combined deficiency of TLR 3/7/9 in the host induces an inflamed tumour phenotype and results in T cell dependent tumour regression after an initial growth.
format	article
author	Johanna C. Klein Katrin Moses Gennadiy Zelinskyy Simon Sody Jan Buer Stephan Lang Iris Helfrich Ulf Dittmer Carsten J. Kirschning Sven Brandau
author_facet	Johanna C. Klein Katrin Moses Gennadiy Zelinskyy Simon Sody Jan Buer Stephan Lang Iris Helfrich Ulf Dittmer Carsten J. Kirschning Sven Brandau
author_sort	Johanna C. Klein
title	Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
title_short	Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
title_full	Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
title_fullStr	Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
title_full_unstemmed	Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth
title_sort	combined toll-like receptor 3/7/9 deficiency on host cells results in t-cell-dependent control of tumour growth
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/88984c6e0d5c4a3888ff0fc853eecb82
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Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth

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