REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES

Children and teenagers aged 10-17 years old with juvenile arthritis (n=99), with reactive arthritis (n=21), with systemic sclerosis (n=16), with systemic lupus erythematosus (n=14) and conditionally healthy (n=32) are investigated. It’s revealed by the method of flow cytometry that quantity of regul...

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Autor principal:	I. A. Pashnina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	regulatory t-cells juvenile arthritis autoimmune diseases children Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/88993cd43eb243efa99e4872a933ac28
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spelling	oai:doaj.org-article:88993cd43eb243efa99e4872a933ac282021-11-18T08:03:43ZREGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES1563-06252313-741X10.15789/1563-0625-2014-4-353-360https://doaj.org/article/88993cd43eb243efa99e4872a933ac282014-08-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/701https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XChildren and teenagers aged 10-17 years old with juvenile arthritis (n=99), with reactive arthritis (n=21), with systemic sclerosis (n=16), with systemic lupus erythematosus (n=14) and conditionally healthy (n=32) are investigated. It’s revealed by the method of flow cytometry that quantity of regulatory T-cells (CD3+CD4+CD25+CD127low/neg) in children with juvenile arthritis, with reactive arthritis and with systemicsclerosis was lower than in the control group. The amount of Treg in children with systemic lupus erythematosus was the same to the control level. The decrease of Treg number in most of investigated groups indicates that these cells are involved in the pathogenesis of an autoimmune diseases in children. It’s remaining unknown what’s the reason of normal Treg content in patients with systemic lupus erythematosus in contrast with other autoimmune diseases. There were positive correlation between the percentage of Treg and the amount ofdamaged joints in children with reactive arthritis and negative correlation between the amount of Treg and SLEDAI in children with systemic lupus erythematosus. The significant correlations between the numbers of CD3+CD25+, CD3+CD4+CD25+ and Treg were revealed, so there isn’t any reasonability of estimation of CD3+ and CD4+cells which are expressed CD25 as separate parameters.I. A. PashninaSPb RAACIarticleregulatory t-cellsjuvenile arthritisautoimmune diseaseschildrenImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 16, Iss 4, Pp 353-360 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	regulatory t-cells juvenile arthritis autoimmune diseases children Immunologic diseases. Allergy RC581-607
spellingShingle	regulatory t-cells juvenile arthritis autoimmune diseases children Immunologic diseases. Allergy RC581-607 I. A. Pashnina REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
description	Children and teenagers aged 10-17 years old with juvenile arthritis (n=99), with reactive arthritis (n=21), with systemic sclerosis (n=16), with systemic lupus erythematosus (n=14) and conditionally healthy (n=32) are investigated. It’s revealed by the method of flow cytometry that quantity of regulatory T-cells (CD3+CD4+CD25+CD127low/neg) in children with juvenile arthritis, with reactive arthritis and with systemicsclerosis was lower than in the control group. The amount of Treg in children with systemic lupus erythematosus was the same to the control level. The decrease of Treg number in most of investigated groups indicates that these cells are involved in the pathogenesis of an autoimmune diseases in children. It’s remaining unknown what’s the reason of normal Treg content in patients with systemic lupus erythematosus in contrast with other autoimmune diseases. There were positive correlation between the percentage of Treg and the amount ofdamaged joints in children with reactive arthritis and negative correlation between the amount of Treg and SLEDAI in children with systemic lupus erythematosus. The significant correlations between the numbers of CD3+CD25+, CD3+CD4+CD25+ and Treg were revealed, so there isn’t any reasonability of estimation of CD3+ and CD4+cells which are expressed CD25 as separate parameters.
format	article
author	I. A. Pashnina
author_facet	I. A. Pashnina
author_sort	I. A. Pashnina
title	REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
title_short	REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
title_full	REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
title_fullStr	REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
title_full_unstemmed	REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES
title_sort	regulatory t-cells in children with autoimmune diseases
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/88993cd43eb243efa99e4872a933ac28
work_keys_str_mv	AT iapashnina regulatorytcellsinchildrenwithautoimmunediseases
_version_	1718422433228128256

REGULATORY T-CELLS IN CHILDREN WITH AUTOIMMUNE DISEASES

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