Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease

Abstract Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of car...

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Autor principal:	Levon M. Khachigian
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cardiovascular disease early growth response‐1 inflammation transcription factors vascular dysfunction Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/889ca57e25ad4d9495459a4e43a39831
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spelling	oai:doaj.org-article:889ca57e25ad4d9495459a4e43a398312021-11-16T10:22:43ZEarly Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease10.1161/JAHA.121.0235392047-9980https://doaj.org/article/889ca57e25ad4d9495459a4e43a398312021-11-01T00:00:00Zhttps://www.ahajournals.org/doi/10.1161/JAHA.121.023539https://doaj.org/toc/2047-9980Abstract Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of cardiovascular and inflammatory disorders. Egr‐1 can amplify pathologic signals from the extracellular environment by serving as a molecular conduit in the inducible expression of proliferative, migratory and proinflammatory genes driving disease progression. Strategies targeting Egr‐1 may provide therapeutic benefit in cardiovascular and inflammatory disorders.Levon M. KhachigianWileyarticlecardiovascular diseaseearly growth response‐1inflammationtranscription factorsvascular dysfunctionDiseases of the circulatory (Cardiovascular) systemRC666-701ENJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 22 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular disease early growth response‐1 inflammation transcription factors vascular dysfunction Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	cardiovascular disease early growth response‐1 inflammation transcription factors vascular dysfunction Diseases of the circulatory (Cardiovascular) system RC666-701 Levon M. Khachigian Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease
description	Abstract Early growth response‐1 (Egr‐1) is a master regulator and transcriptional sensor in vascular dysfunction and disease. This article reviews recent developments in our understanding of the regulatory roles this zinc finger protein and product of an immediate‐early gene plays in a range of cardiovascular and inflammatory disorders. Egr‐1 can amplify pathologic signals from the extracellular environment by serving as a molecular conduit in the inducible expression of proliferative, migratory and proinflammatory genes driving disease progression. Strategies targeting Egr‐1 may provide therapeutic benefit in cardiovascular and inflammatory disorders.
format	article
author	Levon M. Khachigian
author_facet	Levon M. Khachigian
author_sort	Levon M. Khachigian
title	Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease
title_short	Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease
title_full	Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease
title_fullStr	Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease
title_full_unstemmed	Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease
title_sort	early growth response‐1, an integrative sensor in cardiovascular and inflammatory disease
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/889ca57e25ad4d9495459a4e43a39831
work_keys_str_mv	AT levonmkhachigian earlygrowthresponse1anintegrativesensorincardiovascularandinflammatorydisease
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Early Growth Response‐1, an Integrative Sensor in Cardiovascular and Inflammatory Disease

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