Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner

Region-specific increases in hippocampal activity have been reported in schizophrenia patients, yet there are little known about how these circuit levels changes modulate behavioral deficits. Here authors found that that over-expression of the a5 subunit of the GABAA receptor increased tonic GABA cu...

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Autores principales:	J. J. Donegan, A. M. Boley, J. Yamaguchi, G. M. Toney, D. J. Lodge
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88a171ca370b4e079062da3a38e3caff
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spelling	oai:doaj.org-article:88a171ca370b4e079062da3a38e3caff2021-12-02T16:58:18ZModulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner10.1038/s41467-019-10800-12041-1723https://doaj.org/article/88a171ca370b4e079062da3a38e3caff2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10800-1https://doaj.org/toc/2041-1723Region-specific increases in hippocampal activity have been reported in schizophrenia patients, yet there are little known about how these circuit levels changes modulate behavioral deficits. Here authors found that that over-expression of the a5 subunit of the GABAA receptor increased tonic GABA currents and normalized aberrant pyramidal cell activity in the ventral hippocampus which had distinct disease symptom outcomes depending on the pathway targetedJ. J. DoneganA. M. BoleyJ. YamaguchiG. M. ToneyD. J. LodgeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q J. J. Donegan A. M. Boley J. Yamaguchi G. M. Toney D. J. Lodge Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
description	Region-specific increases in hippocampal activity have been reported in schizophrenia patients, yet there are little known about how these circuit levels changes modulate behavioral deficits. Here authors found that that over-expression of the a5 subunit of the GABAA receptor increased tonic GABA currents and normalized aberrant pyramidal cell activity in the ventral hippocampus which had distinct disease symptom outcomes depending on the pathway targeted
format	article
author	J. J. Donegan A. M. Boley J. Yamaguchi G. M. Toney D. J. Lodge
author_facet	J. J. Donegan A. M. Boley J. Yamaguchi G. M. Toney D. J. Lodge
author_sort	J. J. Donegan
title	Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
title_short	Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
title_full	Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
title_fullStr	Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
title_full_unstemmed	Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
title_sort	modulation of extrasynaptic gabaa alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/88a171ca370b4e079062da3a38e3caff
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Modulation of extrasynaptic GABAA alpha 5 receptors in the ventral hippocampus normalizes physiological and behavioral deficits in a circuit specific manner

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