Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice

Background: Gandhaka rasayana (GR) is an important component of many Ayurvedic formulations besides being used as a standalone therapy. However, literature review revealed a chronic toxicity studies with longer duration. Objectives: To delineate the safety profile of GR for 180 days administration i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ravi Mundugaru, Shrinidhi R. Ballal, Sudhakar Bhat, Ravishankar Basavaiah
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Chronic toxicity Gandhaka rasayana Histopathology Miscellaneous systems and treatments RZ409.7-999
Acceso en línea:	https://doaj.org/article/88a5f551802343df8b02f6c15e9a822e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88a5f551802343df8b02f6c15e9a822e
record_format	dspace
spelling	oai:doaj.org-article:88a5f551802343df8b02f6c15e9a822e2021-12-02T04:59:18ZChronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice0975-947610.1016/j.jaim.2021.05.011https://doaj.org/article/88a5f551802343df8b02f6c15e9a822e2021-10-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0975947621001054https://doaj.org/toc/0975-9476Background: Gandhaka rasayana (GR) is an important component of many Ayurvedic formulations besides being used as a standalone therapy. However, literature review revealed a chronic toxicity studies with longer duration. Objectives: To delineate the safety profile of GR for 180 days administration in rats. Materials and methods: Wistar albino rats of both sexes weighing 150 ± 10 g body weight in groups of 20 (10 male and 10 female) for each of the three GR dose levels i.e., 0.54 g, 1.08 g, and 5.4 g/kg were employed. Carboxyl methyl cellulose was administered to the control group in equal volume. Toxicity was assessed based on the changes observed, compared to control, in body weight gain, food and water consumption, organ weight and histopathology, clinical biochemistry, and hematological parameters as per AYUSH guidelines. Results: GR repeated dose administration caused significant changes in body weight gain, organ ponderal changes, few hematologic and biochemical parameters. Male rats administered with GR at 1.08 g/kg dose showed a significant decrease in the MCV and MCH compared to control, whereas female rat’s administred with 1.08 g/kg and 0.54 g/kg dose showed a significant increase in the MCV and MCH. GR administered at 0.54 g/kg showed a significant increase in the serum glucose level in male rats, whereas female rats showed a significant elevation in the cholesterol level. GR at 0.54 g/kg and 5.4 g/kg showed a significant elevation in the serum SGPT level in male rats. These changes were not observed in female rats. Histological examination revealed mild pathological changes in organs like kidney, liver, spleen and jejunum. Conclusion: The data generated shows that GR is safe and does not have any toxicity potential at the doses used in therapeutics. Some of the changes observed were at higher dose levels which is not likely to be used clinically.Ravi MundugaruShrinidhi R. BallalSudhakar BhatRavishankar BasavaiahElsevierarticleChronic toxicityGandhaka rasayanaHistopathologyMiscellaneous systems and treatmentsRZ409.7-999ENJournal of Ayurveda and Integrative Medicine, Vol 12, Iss 4, Pp 673-681 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic toxicity Gandhaka rasayana Histopathology Miscellaneous systems and treatments RZ409.7-999
spellingShingle	Chronic toxicity Gandhaka rasayana Histopathology Miscellaneous systems and treatments RZ409.7-999 Ravi Mundugaru Shrinidhi R. Ballal Sudhakar Bhat Ravishankar Basavaiah Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice
description	Background: Gandhaka rasayana (GR) is an important component of many Ayurvedic formulations besides being used as a standalone therapy. However, literature review revealed a chronic toxicity studies with longer duration. Objectives: To delineate the safety profile of GR for 180 days administration in rats. Materials and methods: Wistar albino rats of both sexes weighing 150 ± 10 g body weight in groups of 20 (10 male and 10 female) for each of the three GR dose levels i.e., 0.54 g, 1.08 g, and 5.4 g/kg were employed. Carboxyl methyl cellulose was administered to the control group in equal volume. Toxicity was assessed based on the changes observed, compared to control, in body weight gain, food and water consumption, organ weight and histopathology, clinical biochemistry, and hematological parameters as per AYUSH guidelines. Results: GR repeated dose administration caused significant changes in body weight gain, organ ponderal changes, few hematologic and biochemical parameters. Male rats administered with GR at 1.08 g/kg dose showed a significant decrease in the MCV and MCH compared to control, whereas female rat’s administred with 1.08 g/kg and 0.54 g/kg dose showed a significant increase in the MCV and MCH. GR administered at 0.54 g/kg showed a significant increase in the serum glucose level in male rats, whereas female rats showed a significant elevation in the cholesterol level. GR at 0.54 g/kg and 5.4 g/kg showed a significant elevation in the serum SGPT level in male rats. These changes were not observed in female rats. Histological examination revealed mild pathological changes in organs like kidney, liver, spleen and jejunum. Conclusion: The data generated shows that GR is safe and does not have any toxicity potential at the doses used in therapeutics. Some of the changes observed were at higher dose levels which is not likely to be used clinically.
format	article
author	Ravi Mundugaru Shrinidhi R. Ballal Sudhakar Bhat Ravishankar Basavaiah
author_facet	Ravi Mundugaru Shrinidhi R. Ballal Sudhakar Bhat Ravishankar Basavaiah
author_sort	Ravi Mundugaru
title	Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice
title_short	Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice
title_full	Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice
title_fullStr	Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice
title_full_unstemmed	Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice
title_sort	chronic toxicity studies of gandhaka rasayana - a herbo-mineral preparation used in ayurvedic practice
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/88a5f551802343df8b02f6c15e9a822e
work_keys_str_mv	AT ravimundugaru chronictoxicitystudiesofgandhakarasayanaaherbomineralpreparationusedinayurvedicpractice AT shrinidhirballal chronictoxicitystudiesofgandhakarasayanaaherbomineralpreparationusedinayurvedicpractice AT sudhakarbhat chronictoxicitystudiesofgandhakarasayanaaherbomineralpreparationusedinayurvedicpractice AT ravishankarbasavaiah chronictoxicitystudiesofgandhakarasayanaaherbomineralpreparationusedinayurvedicpractice
_version_	1718400900586799104

Chronic toxicity studies of gandhaka rasayana - A herbo-mineral preparation used in Ayurvedic practice

Ejemplares similares