Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2020
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/88a744a3686041109c4ea736e41cbe54 |
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| Sumario: | Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant. |
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