Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation

Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant...

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Autores principales:	Xianxiao Chen, Weidong Rao, Tao Yang, Ming Joo Koh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88a744a3686041109c4ea736e41cbe54
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spelling	oai:doaj.org-article:88a744a3686041109c4ea736e41cbe542021-12-02T14:41:14ZAlkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation10.1038/s41467-020-19717-62041-1723https://doaj.org/article/88a744a3686041109c4ea736e41cbe542020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19717-6https://doaj.org/toc/2041-1723Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant.Xianxiao ChenWeidong RaoTao YangMing Joo KohNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xianxiao Chen Weidong Rao Tao Yang Ming Joo Koh Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
description	Methods that regioselectively install a functionalized alkyl unit at the 2-position of a terminal unactivated C=C bond are scarce. Here, the authors report a Markovnikov-selective hydroalkylation of unactivated amide-tethered alkenes catalyzed by nickel in conjunction with a stoichiometric reductant.
format	article
author	Xianxiao Chen Weidong Rao Tao Yang Ming Joo Koh
author_facet	Xianxiao Chen Weidong Rao Tao Yang Ming Joo Koh
author_sort	Xianxiao Chen
title	Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
title_short	Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
title_full	Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
title_fullStr	Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
title_full_unstemmed	Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
title_sort	alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/88a744a3686041109c4ea736e41cbe54
work_keys_str_mv	AT xianxiaochen alkylhalidesasbothhydrideandalkylsourcesincatalyticregioselectivereductiveolefinhydroalkylation AT weidongrao alkylhalidesasbothhydrideandalkylsourcesincatalyticregioselectivereductiveolefinhydroalkylation AT taoyang alkylhalidesasbothhydrideandalkylsourcesincatalyticregioselectivereductiveolefinhydroalkylation AT mingjookoh alkylhalidesasbothhydrideandalkylsourcesincatalyticregioselectivereductiveolefinhydroalkylation
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Alkyl halides as both hydride and alkyl sources in catalytic regioselective reductive olefin hydroalkylation

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