Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

Mild heat stress has beneficial effects on organismal health and survival. Here, Kumstaet al. show that a mild heat shock and HSF-1 overexpression induce autophagy in multiple tissues of C. elegansand autophagy-related genes are essential for both heat shock-induced and HSF-1–mediated stress resista...

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Autores principales:	Caroline Kumsta, Jessica T. Chang, Jessica Schmalz, Malene Hansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88a82688b15d44639dd224cca7456959
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spelling	oai:doaj.org-article:88a82688b15d44639dd224cca74569592021-12-02T16:51:42ZHormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans10.1038/ncomms143372041-1723https://doaj.org/article/88a82688b15d44639dd224cca74569592017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14337https://doaj.org/toc/2041-1723Mild heat stress has beneficial effects on organismal health and survival. Here, Kumstaet al. show that a mild heat shock and HSF-1 overexpression induce autophagy in multiple tissues of C. elegansand autophagy-related genes are essential for both heat shock-induced and HSF-1–mediated stress resistance and longevity.Caroline KumstaJessica T. ChangJessica SchmalzMalene HansenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Caroline Kumsta Jessica T. Chang Jessica Schmalz Malene Hansen Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
description	Mild heat stress has beneficial effects on organismal health and survival. Here, Kumstaet al. show that a mild heat shock and HSF-1 overexpression induce autophagy in multiple tissues of C. elegansand autophagy-related genes are essential for both heat shock-induced and HSF-1–mediated stress resistance and longevity.
format	article
author	Caroline Kumsta Jessica T. Chang Jessica Schmalz Malene Hansen
author_facet	Caroline Kumsta Jessica T. Chang Jessica Schmalz Malene Hansen
author_sort	Caroline Kumsta
title	Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
title_short	Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
title_full	Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
title_fullStr	Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
title_full_unstemmed	Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans
title_sort	hormetic heat stress and hsf-1 induce autophagy to improve survival and proteostasis in c. elegans
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/88a82688b15d44639dd224cca7456959
work_keys_str_mv	AT carolinekumsta hormeticheatstressandhsf1induceautophagytoimprovesurvivalandproteostasisincelegans AT jessicatchang hormeticheatstressandhsf1induceautophagytoimprovesurvivalandproteostasisincelegans AT jessicaschmalz hormeticheatstressandhsf1induceautophagytoimprovesurvivalandproteostasisincelegans AT malenehansen hormeticheatstressandhsf1induceautophagytoimprovesurvivalandproteostasisincelegans
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Hormetic heat stress and HSF-1 induce autophagy to improve survival and proteostasis in C. elegans

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