Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles

Zhaoqing Cong, Feifei Yang, Li Cao, Han Wen, Taotao Fu, Siqi Ma, Chunyu Liu, Lihui Quan, Yonghong Liao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical...

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Autores principales:	Cong ZQ, Yang FF, Cao L, Wen H, Fu TT, Ma SQ, Liu CY, Quan LH, Liao YH
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Multispectral optoacoustic tomography (MSOT) Polymeric micelle In vivo imaging Intratumoral distribution Particle size Tumor model. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88a963dc203545ab8e74916f67b8045b
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spelling	oai:doaj.org-article:88a963dc203545ab8e74916f67b8045b2021-12-02T01:18:42ZMultispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles1178-2013https://doaj.org/article/88a963dc203545ab8e74916f67b8045b2018-12-01T00:00:00Zhttps://www.dovepress.com/multispectral-optoacoustic-tomography-msot-for-imaging-the-particle-si-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zhaoqing Cong, Feifei Yang, Li Cao, Han Wen, Taotao Fu, Siqi Ma, Chunyu Liu, Lihui Quan, Yonghong Liao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haidian District, Beijing 100193, People’s Republic of China Purpose: This study proposes the utilization of multispectral optoacoustic tomography (MSOT) to investigate the intratumoral distribution of polymeric micelles and effect of size on the biodistribution and antitumor efficacy (ATE). Materials and methods: Docetaxel and/or optoacoustic agent-loaded polymeric micelles (with diameters of 22, 48, and 124 nm) were prepared using amphiphilic block copolymers poly (ethylene glycol) methyl ether-block-poly (D,L lactide) (PEG2000–PDLLAx). Subcutaneous 4T1 tumor-bearing mice were monitored with MSOT imaging and IVIS® Spectrum in vivo live imaging after tail vein injection of micelles. The in vivo results and ex vivo confocal imaging results were then compared. Next, ATE of the three micelles was found and compared. Results: We found that MSOT imaging offers spatiotemporal and quantitative information on intratumoral distribution of micelles in living animals. All the polymeric micelles rapidly extravasated into tumor site after intravenous injection, but only the 22-nm micelle preferred to distribute into the inner tumor tissues, leading to a superior ATE than that of 48- and 124-nm micelles. Conclusion: This study demonstrated that MSOT is theranostically a powerful imaging modality, offering quantitative information on size-dependent spatiotemporal distribution patterns after the extravasation of nanomedicine from tumor blood vessels. Keywords: multispectral optoacoustic tomography, MSOT, polymeric micelle, in vivo imaging, intratumoral distribution, particle size, tumor modelCong ZQYang FFCao LWen HFu TTMa SQLiu CYQuan LHLiao YHDove Medical PressarticleMultispectral optoacoustic tomography (MSOT)Polymeric micelleIn vivo imagingIntratumoral distributionParticle sizeTumor model.Medicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 8549-8560 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multispectral optoacoustic tomography (MSOT) Polymeric micelle In vivo imaging Intratumoral distribution Particle size Tumor model. Medicine (General) R5-920
spellingShingle	Multispectral optoacoustic tomography (MSOT) Polymeric micelle In vivo imaging Intratumoral distribution Particle size Tumor model. Medicine (General) R5-920 Cong ZQ Yang FF Cao L Wen H Fu TT Ma SQ Liu CY Quan LH Liao YH Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
description	Zhaoqing Cong, Feifei Yang, Li Cao, Han Wen, Taotao Fu, Siqi Ma, Chunyu Liu, Lihui Quan, Yonghong Liao Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Haidian District, Beijing 100193, People’s Republic of China Purpose: This study proposes the utilization of multispectral optoacoustic tomography (MSOT) to investigate the intratumoral distribution of polymeric micelles and effect of size on the biodistribution and antitumor efficacy (ATE). Materials and methods: Docetaxel and/or optoacoustic agent-loaded polymeric micelles (with diameters of 22, 48, and 124 nm) were prepared using amphiphilic block copolymers poly (ethylene glycol) methyl ether-block-poly (D,L lactide) (PEG2000–PDLLAx). Subcutaneous 4T1 tumor-bearing mice were monitored with MSOT imaging and IVIS® Spectrum in vivo live imaging after tail vein injection of micelles. The in vivo results and ex vivo confocal imaging results were then compared. Next, ATE of the three micelles was found and compared. Results: We found that MSOT imaging offers spatiotemporal and quantitative information on intratumoral distribution of micelles in living animals. All the polymeric micelles rapidly extravasated into tumor site after intravenous injection, but only the 22-nm micelle preferred to distribute into the inner tumor tissues, leading to a superior ATE than that of 48- and 124-nm micelles. Conclusion: This study demonstrated that MSOT is theranostically a powerful imaging modality, offering quantitative information on size-dependent spatiotemporal distribution patterns after the extravasation of nanomedicine from tumor blood vessels. Keywords: multispectral optoacoustic tomography, MSOT, polymeric micelle, in vivo imaging, intratumoral distribution, particle size, tumor model
format	article
author	Cong ZQ Yang FF Cao L Wen H Fu TT Ma SQ Liu CY Quan LH Liao YH
author_facet	Cong ZQ Yang FF Cao L Wen H Fu TT Ma SQ Liu CY Quan LH Liao YH
author_sort	Cong ZQ
title	Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
title_short	Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
title_full	Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
title_fullStr	Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
title_full_unstemmed	Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
title_sort	multispectral optoacoustic tomography (msot) for imaging the particle size-dependent intratumoral distribution of polymeric micelles
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/88a963dc203545ab8e74916f67b8045b
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Multispectral optoacoustic tomography (MSOT) for imaging the particle size-dependent intratumoral distribution of polymeric micelles

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