The use of directed evolution to create a stable and immunogenic recombinant BCG expressing a modified HIV-1 Gag antigen.

Numerous features make Mycobacterium bovis BCG an attractive vaccine vector for HIV. It has a good safety profile, it elicits long-lasting cellular immune responses and in addition manufacturing costs are affordable. Despite these advantages it is often difficult to express viral antigens in BCG, wh...

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Autores principales: Rosamund Chapman, William R Bourn, Enid Shephard, Helen Stutz, Nicola Douglass, Thandi Mgwebi, Ann Meyers, Nyasha Chin'ombe, Anna-Lise Williamson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/88b4227fa0fd4e378189e633d326ac10
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