Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Many reagents have been developed for cysteine-specific protein modification. However, few of them allow for multi-functionalization of a single Cys residue and disulfide bridging bioconjugation. Here the authors report 3-bromo-5-methylene pyrrolones as a simple, robust and versatile class of reagen...

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Autores principales:	Yingqian Zhang, Chuanlong Zang, Guoce An, Mengdi Shang, Zenghui Cui, Gong Chen, Zhen Xi, Chuanzheng Zhou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88ba4e15e7d64589b76fbb9981def688
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spelling	oai:doaj.org-article:88ba4e15e7d64589b76fbb9981def6882021-12-02T16:56:49ZCysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones10.1038/s41467-020-14757-42041-1723https://doaj.org/article/88ba4e15e7d64589b76fbb9981def6882020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14757-4https://doaj.org/toc/2041-1723Many reagents have been developed for cysteine-specific protein modification. However, few of them allow for multi-functionalization of a single Cys residue and disulfide bridging bioconjugation. Here the authors report 3-bromo-5-methylene pyrrolones as a simple, robust and versatile class of reagents for cysteine-specific protein modification.Yingqian ZhangChuanlong ZangGuoce AnMengdi ShangZenghui CuiGong ChenZhen XiChuanzheng ZhouNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yingqian Zhang Chuanlong Zang Guoce An Mengdi Shang Zenghui Cui Gong Chen Zhen Xi Chuanzheng Zhou Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
description	Many reagents have been developed for cysteine-specific protein modification. However, few of them allow for multi-functionalization of a single Cys residue and disulfide bridging bioconjugation. Here the authors report 3-bromo-5-methylene pyrrolones as a simple, robust and versatile class of reagents for cysteine-specific protein modification.
format	article
author	Yingqian Zhang Chuanlong Zang Guoce An Mengdi Shang Zenghui Cui Gong Chen Zhen Xi Chuanzheng Zhou
author_facet	Yingqian Zhang Chuanlong Zang Guoce An Mengdi Shang Zenghui Cui Gong Chen Zhen Xi Chuanzheng Zhou
author_sort	Yingqian Zhang
title	Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
title_short	Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
title_full	Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
title_fullStr	Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
title_full_unstemmed	Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
title_sort	cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/88ba4e15e7d64589b76fbb9981def688
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Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

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