m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

FTO is an m6A demethylase. Here, the authors show that FTO promotes melanoma tumorigenicity and contributes to resistance to anti-PD1 blockade, while FTO inhibition sensitizes melanoma to anti-PD1 blockade.

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Autores principales:	Seungwon Yang, Jiangbo Wei, Yan-Hong Cui, Gayoung Park, Palak Shah, Yu Deng, Andrew E. Aplin, Zhike Lu, Seungmin Hwang, Chuan He, Yu-Ying He
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88c0f0ec32fd485b963c5d3ea0d66653
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spelling	oai:doaj.org-article:88c0f0ec32fd485b963c5d3ea0d666532021-12-02T15:36:04Zm6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade10.1038/s41467-019-10669-02041-1723https://doaj.org/article/88c0f0ec32fd485b963c5d3ea0d666532019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10669-0https://doaj.org/toc/2041-1723FTO is an m6A demethylase. Here, the authors show that FTO promotes melanoma tumorigenicity and contributes to resistance to anti-PD1 blockade, while FTO inhibition sensitizes melanoma to anti-PD1 blockade.Seungwon YangJiangbo WeiYan-Hong CuiGayoung ParkPalak ShahYu DengAndrew E. AplinZhike LuSeungmin HwangChuan HeYu-Ying HeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Seungwon Yang Jiangbo Wei Yan-Hong Cui Gayoung Park Palak Shah Yu Deng Andrew E. Aplin Zhike Lu Seungmin Hwang Chuan He Yu-Ying He m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
description	FTO is an m6A demethylase. Here, the authors show that FTO promotes melanoma tumorigenicity and contributes to resistance to anti-PD1 blockade, while FTO inhibition sensitizes melanoma to anti-PD1 blockade.
format	article
author	Seungwon Yang Jiangbo Wei Yan-Hong Cui Gayoung Park Palak Shah Yu Deng Andrew E. Aplin Zhike Lu Seungmin Hwang Chuan He Yu-Ying He
author_facet	Seungwon Yang Jiangbo Wei Yan-Hong Cui Gayoung Park Palak Shah Yu Deng Andrew E. Aplin Zhike Lu Seungmin Hwang Chuan He Yu-Ying He
author_sort	Seungwon Yang
title	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
title_short	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
title_full	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
title_fullStr	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
title_full_unstemmed	m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade
title_sort	m6a mrna demethylase fto regulates melanoma tumorigenicity and response to anti-pd-1 blockade
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/88c0f0ec32fd485b963c5d3ea0d66653
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m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade

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