Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.

Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.

Circulating immature platelet fraction (IPF) reflects real-time thrombopoiesis and correlates with platelet recovery from thrombocytopenic presentations. To understand the dynamics of IPF in platelet transfusions, we quantified the %-IPF in single-donor platelet components (SDP) during prolonged sto...

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Autores principales: Hong Hong, Wenbin Xiao, Robert W Maitta
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/88c16481ec8b4261a6dbd75d229d3cb3
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spelling oai:doaj.org-article:88c16481ec8b4261a6dbd75d229d3cb32021-11-18T08:38:22ZSteady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.1932-620310.1371/journal.pone.0085465https://doaj.org/article/88c16481ec8b4261a6dbd75d229d3cb32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24416412/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Circulating immature platelet fraction (IPF) reflects real-time thrombopoiesis and correlates with platelet recovery from thrombocytopenic presentations. To understand the dynamics of IPF in platelet transfusions, we quantified the %-IPF in single-donor platelet components (SDP) during prolonged storage. %-IPF significantly increased from baseline by day 5 post-donation. Absolute IPF counts (A-IPC) had similar significant increments. However, gamma-irradiation suppressed the increments of %-IPF and A-IPC by >50%. Ultrastructural analysis of SDP units at day 10 showed well preserved morphology of immature platelets. Our findings suggest that IPF might actively expand ex-vivo and may have a longer shelf life than their mature counterparts. Closer study of IPF may be of critical clinical importance for transfusion practices.Hong HongWenbin XiaoRobert W MaittaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e85465 (2014)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
Hong Hong
Wenbin Xiao
Robert W Maitta
Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
description Circulating immature platelet fraction (IPF) reflects real-time thrombopoiesis and correlates with platelet recovery from thrombocytopenic presentations. To understand the dynamics of IPF in platelet transfusions, we quantified the %-IPF in single-donor platelet components (SDP) during prolonged storage. %-IPF significantly increased from baseline by day 5 post-donation. Absolute IPF counts (A-IPC) had similar significant increments. However, gamma-irradiation suppressed the increments of %-IPF and A-IPC by >50%. Ultrastructural analysis of SDP units at day 10 showed well preserved morphology of immature platelets. Our findings suggest that IPF might actively expand ex-vivo and may have a longer shelf life than their mature counterparts. Closer study of IPF may be of critical clinical importance for transfusion practices.
format article
author Hong Hong
Wenbin Xiao
Robert W Maitta
author_facet Hong Hong
Wenbin Xiao
Robert W Maitta
author_sort Hong Hong
title Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
title_short Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
title_full Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
title_fullStr Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
title_full_unstemmed Steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
title_sort steady increment of immature platelet fraction is suppressed by irradiation in single-donor platelet components during storage.
publisher Public Library of Science (PLoS)
publishDate 2014
url https://doaj.org/article/88c16481ec8b4261a6dbd75d229d3cb3
work_keys_str_mv AT honghong steadyincrementofimmatureplateletfractionissuppressedbyirradiationinsingledonorplateletcomponentsduringstorage
AT wenbinxiao steadyincrementofimmatureplateletfractionissuppressedbyirradiationinsingledonorplateletcomponentsduringstorage
AT robertwmaitta steadyincrementofimmatureplateletfractionissuppressedbyirradiationinsingledonorplateletcomponentsduringstorage
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