Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management...

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Autores principales:	Junyao Cheng, Jianheng Liu, Ming Li, Zhongyang Liu, Xing Wang, Licheng Zhang, Zheng Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	hydrogel hemostasis wound healing nature-derived polysaccharides nature-derived proteins Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/88c17b26f8cc47358e95ddc03bbbd015
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spelling	oai:doaj.org-article:88c17b26f8cc47358e95ddc03bbbd0152021-11-22T06:41:00ZHydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing2296-418510.3389/fbioe.2021.780187https://doaj.org/article/88c17b26f8cc47358e95ddc03bbbd0152021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fbioe.2021.780187/fullhttps://doaj.org/toc/2296-4185Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management of uncontrollable bleeding, resulting in widespread interest in the development of novel hemostatic materials and techniques. Benefiting from biocompatibility, degradability, injectability, tunable mechanical properties, and potential abilities to promote coagulation, wound healing, and anti-infection, hydrogel-based biomaterials, especially those on the basis of natural polysaccharides and proteins, have been increasingly explored in preclinical studies over the past few years. Despite the exciting research progress and initial commercial development of several hemostatic hydrogels, there is still a significant distance from the desired hemostatic effect applicable to clinical treatment. In this review, after elucidating the process of biological hemostasis, the latest progress of hydrogel biomaterials engineered from natural polysaccharides and proteins for hemostasis is discussed on the basis of comprehensive literature review. We have focused on the preparation strategies, physicochemical properties, hemostatic and wound-healing abilities of these novel biomaterials, and highlighted the challenges that needed to be addressed to achieve the transformation of laboratory research into clinical practice, and finally presented future research directions in this area.Junyao ChengJunyao ChengJianheng LiuMing LiZhongyang LiuXing WangXing WangLicheng ZhangZheng WangFrontiers Media S.A.articlehydrogelhemostasiswound healingnature-derived polysaccharidesnature-derived proteinsBiotechnologyTP248.13-248.65ENFrontiers in Bioengineering and Biotechnology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hydrogel hemostasis wound healing nature-derived polysaccharides nature-derived proteins Biotechnology TP248.13-248.65
spellingShingle	hydrogel hemostasis wound healing nature-derived polysaccharides nature-derived proteins Biotechnology TP248.13-248.65 Junyao Cheng Junyao Cheng Jianheng Liu Ming Li Zhongyang Liu Xing Wang Xing Wang Licheng Zhang Zheng Wang Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
description	Rapid and effective hemostasis is of great importance to improve the quality of treatment and save lives in emergency, surgical practice, civilian, and military settings. Traditional hemostatic materials such as tourniquets, gauze, bandages, and sponges have shown limited efficacy in the management of uncontrollable bleeding, resulting in widespread interest in the development of novel hemostatic materials and techniques. Benefiting from biocompatibility, degradability, injectability, tunable mechanical properties, and potential abilities to promote coagulation, wound healing, and anti-infection, hydrogel-based biomaterials, especially those on the basis of natural polysaccharides and proteins, have been increasingly explored in preclinical studies over the past few years. Despite the exciting research progress and initial commercial development of several hemostatic hydrogels, there is still a significant distance from the desired hemostatic effect applicable to clinical treatment. In this review, after elucidating the process of biological hemostasis, the latest progress of hydrogel biomaterials engineered from natural polysaccharides and proteins for hemostasis is discussed on the basis of comprehensive literature review. We have focused on the preparation strategies, physicochemical properties, hemostatic and wound-healing abilities of these novel biomaterials, and highlighted the challenges that needed to be addressed to achieve the transformation of laboratory research into clinical practice, and finally presented future research directions in this area.
format	article
author	Junyao Cheng Junyao Cheng Jianheng Liu Ming Li Zhongyang Liu Xing Wang Xing Wang Licheng Zhang Zheng Wang
author_facet	Junyao Cheng Junyao Cheng Jianheng Liu Ming Li Zhongyang Liu Xing Wang Xing Wang Licheng Zhang Zheng Wang
author_sort	Junyao Cheng
title	Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
title_short	Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
title_full	Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
title_fullStr	Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
title_full_unstemmed	Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing
title_sort	hydrogel-based biomaterials engineered from natural-derived polysaccharides and proteins for hemostasis and wound healing
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/88c17b26f8cc47358e95ddc03bbbd015
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Hydrogel-Based Biomaterials Engineered from Natural-Derived Polysaccharides and Proteins for Hemostasis and Wound Healing

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