Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.

Guizhou semi-fine wool sheep are affected by a disease, characterized by emaciation, lameness, stiffness in the gait, enlargement of the costochondral junctions, and abnormal curvature in the long bones. The objective of this study was to determine possible relationships between the disease and mine...

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Autores principales:	Xiaoyun Shen, Jinhua Zhang, Renduo Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88c3054ea2ef4d2b8847089506bdcfa7
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spelling	oai:doaj.org-article:88c3054ea2ef4d2b8847089506bdcfa72021-11-18T08:31:54ZPhosphorus metabolic disorder of Guizhou semi-fine wool sheep.1932-620310.1371/journal.pone.0089472https://doaj.org/article/88c3054ea2ef4d2b8847089506bdcfa72014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24586803/?tool=EBIhttps://doaj.org/toc/1932-6203Guizhou semi-fine wool sheep are affected by a disease, characterized by emaciation, lameness, stiffness in the gait, enlargement of the costochondral junctions, and abnormal curvature in the long bones. The objective of this study was to determine possible relationships between the disease and mineral deficiencies. Samples of tissue and blood were collected from affected and unaffected sheep. Samples of soil and forage were collected from affected and unaffected areas. The samples were used for biochemical analyses and mineral nutrient measurements. Results showed that phosphorus (P) concentrations in forage samples from affected areas were significantly lower than those from unaffected areas (P < 0.01) and the mean ratio of calcium (Ca) to P in the affected forage was 12:1. Meanwhile, P concentrations of blood, bone, tooth, and wool from the affected sheep were also significantly lower than those from the unaffected group (P < 0.01). Serum P levels of the affected animals were much lower than those of the unaffected ones, whereas serum alkaline phosphatase levels from the affected were significantly higher than those from the unaffected (P < 0.01). Inorganic P levels of the affected sheep were about half of those in the control group. Oral administration of disodium hydrogen phosphate prevented and cured the disease. The study clearly demonstrated that the disease of Guizhou semi-fine wool sheep was mainly caused by the P deficiency in forage, as a result of fenced pasture and animal habitat fragmentation.Xiaoyun ShenJinhua ZhangRenduo ZhangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89472 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaoyun Shen Jinhua Zhang Renduo Zhang Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.
description	Guizhou semi-fine wool sheep are affected by a disease, characterized by emaciation, lameness, stiffness in the gait, enlargement of the costochondral junctions, and abnormal curvature in the long bones. The objective of this study was to determine possible relationships between the disease and mineral deficiencies. Samples of tissue and blood were collected from affected and unaffected sheep. Samples of soil and forage were collected from affected and unaffected areas. The samples were used for biochemical analyses and mineral nutrient measurements. Results showed that phosphorus (P) concentrations in forage samples from affected areas were significantly lower than those from unaffected areas (P < 0.01) and the mean ratio of calcium (Ca) to P in the affected forage was 12:1. Meanwhile, P concentrations of blood, bone, tooth, and wool from the affected sheep were also significantly lower than those from the unaffected group (P < 0.01). Serum P levels of the affected animals were much lower than those of the unaffected ones, whereas serum alkaline phosphatase levels from the affected were significantly higher than those from the unaffected (P < 0.01). Inorganic P levels of the affected sheep were about half of those in the control group. Oral administration of disodium hydrogen phosphate prevented and cured the disease. The study clearly demonstrated that the disease of Guizhou semi-fine wool sheep was mainly caused by the P deficiency in forage, as a result of fenced pasture and animal habitat fragmentation.
format	article
author	Xiaoyun Shen Jinhua Zhang Renduo Zhang
author_facet	Xiaoyun Shen Jinhua Zhang Renduo Zhang
author_sort	Xiaoyun Shen
title	Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.
title_short	Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.
title_full	Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.
title_fullStr	Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.
title_full_unstemmed	Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.
title_sort	phosphorus metabolic disorder of guizhou semi-fine wool sheep.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/88c3054ea2ef4d2b8847089506bdcfa7
work_keys_str_mv	AT xiaoyunshen phosphorusmetabolicdisorderofguizhousemifinewoolsheep AT jinhuazhang phosphorusmetabolicdisorderofguizhousemifinewoolsheep AT renduozhang phosphorusmetabolicdisorderofguizhousemifinewoolsheep
_version_	1718421694378409984

Phosphorus metabolic disorder of Guizhou semi-fine wool sheep.

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