Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus

The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infe...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mathieu Long, Johan Toesca, Christophe Guillon
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	Feline Immunodeficiency Virus FIV Human Immunodeficiency Virus HIV Gag matrix Medicine R
Acceso en línea:	https://doaj.org/article/88c4d5f7be1044678c80a8a7afdba760
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88c4d5f7be1044678c80a8a7afdba760
record_format	dspace
spelling	oai:doaj.org-article:88c4d5f7be1044678c80a8a7afdba7602021-11-25T18:38:45ZReview and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus10.3390/pathogens101115022076-0817https://doaj.org/article/88c4d5f7be1044678c80a8a7afdba7602021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1502https://doaj.org/toc/2076-0817The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure–function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein.Mathieu LongJohan ToescaChristophe GuillonMDPI AGarticleFeline Immunodeficiency VirusFIVHuman Immunodeficiency VirusHIVGagmatrixMedicineRENPathogens, Vol 10, Iss 1502, p 1502 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Feline Immunodeficiency Virus FIV Human Immunodeficiency Virus HIV Gag matrix Medicine R
spellingShingle	Feline Immunodeficiency Virus FIV Human Immunodeficiency Virus HIV Gag matrix Medicine R Mathieu Long Johan Toesca Christophe Guillon Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
description	The Gag polyprotein is implied in the budding as well as the establishment of the supramolecular architecture of infectious retroviral particles. It is also involved in the early phases of the replication of retroviruses by protecting and transporting the viral genome towards the nucleus of the infected cell until its integration in the host genome. Therefore, understanding the structure–function relationships of the Gag subunits is crucial as each of them can represent a therapeutic target. Though the field has been explored for some time in the area of Human Immunodeficiency Virus (HIV), it is only in the last decade that structural data on Feline Immunodeficiency Virus (FIV) Gag subunits have emerged. As FIV is an important veterinary issue, both in domestic cats and endangered feline species, such data are of prime importance for the development of anti-FIV molecules targeting Gag. This review will focus on the recent advances and perspectives on the structure–function relationships of each subunit of the FIV Gag polyprotein.
format	article
author	Mathieu Long Johan Toesca Christophe Guillon
author_facet	Mathieu Long Johan Toesca Christophe Guillon
author_sort	Mathieu Long
title	Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
title_short	Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
title_full	Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
title_fullStr	Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
title_full_unstemmed	Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus
title_sort	review and perspectives on the structure–function relationships of the gag subunits of feline immunodeficiency virus
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/88c4d5f7be1044678c80a8a7afdba760
work_keys_str_mv	AT mathieulong reviewandperspectivesonthestructurefunctionrelationshipsofthegagsubunitsoffelineimmunodeficiencyvirus AT johantoesca reviewandperspectivesonthestructurefunctionrelationshipsofthegagsubunitsoffelineimmunodeficiencyvirus AT christopheguillon reviewandperspectivesonthestructurefunctionrelationshipsofthegagsubunitsoffelineimmunodeficiencyvirus
_version_	1718410846674092032

Review and Perspectives on the Structure–Function Relationships of the Gag Subunits of Feline Immunodeficiency Virus

Ejemplares similares