The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population

Chun-Ming Ma,1 Ning Wang,2 Quan-Wei Su,3 Ying Yan,3 Fu-Zai Yin1 1Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of China; 2Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of C...

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Autores principales:	Ma CM, Wang N, Su QW, Yan Y, Yin FZ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	community-acquired pneumonia curb-65 pneumonia severity index mortality type 2 diabetes Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/88c59d4b9db54acbbeceedcc0eda9292
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spelling	oai:doaj.org-article:88c59d4b9db54acbbeceedcc0eda92922021-12-02T17:06:26ZThe Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population1178-7007https://doaj.org/article/88c59d4b9db54acbbeceedcc0eda92922021-03-01T00:00:00Zhttps://www.dovepress.com/the-performance-of-curb-65-and-psi-for-predicting-in-hospital-mortalit-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Chun-Ming Ma,1 Ning Wang,2 Quan-Wei Su,3 Ying Yan,3 Fu-Zai Yin1 1Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of China; 2Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Internal Medicine, Chengde Medical College, Chengde, Hebei, People’s Republic of ChinaCorrespondence: Fu-Zai Yin Email yinfuzai62@163.comObjective: To compare the performance of CURB-65 and Pneumonia Severity Index (PSI) for predicting in-hospital mortality of community-acquired pneumonia (CAP) between patients with and without type 2 diabetes (T2DM).Methods: A retrospective study was conducted on 2365 CAP patients in The First Hospital of Qinhuangdao, China. The primary outcome was in-hospital mortality. The area under curves (AUCs) was used to evaluate the abilities of CRB-65, CURB-65, and PSI class for predicting in-hospital mortality in patients with CAP.Results: Among CAP patients, 127 patients (5.4%) died, 80 patients were without diabetes, and 47 patients had T2DM. In-hospital mortality increased with the risk stratification defined as CURB-65 and PSI class in both non-diabetes and T2DM patients (P< 0.05). The AUCs for predicting in-hospital mortality were 0.728～0.798 in patients without T2DM (CRB-65: 0.728, CURB-65: 0.757 and PSI class: 0.798) and 0.641～0.716 in patients with T2DM (CRB-65: 0.641, CURB-65: 0.677 and PSI class: 0.716)(P< 0.001). The AUC of the PSI class was lower in patients with T2DM than in patients without T2DM (P< 0.05).Conclusion: CURB-65 and PSI class are correlated with in-hospital mortality of CAP in patients with and without T2DM. Compared with non-diabetes patients, the predictive performance of CURB-65 and PSI class decreased in patients with T2DM. A prediction model for evaluating the CAP severity in the T2DM population should be developed by future studies.Keywords: community-acquired pneumonia, CURB-65, pneumonia severity index, mortality, type 2 diabetesMa CMWang NSu QWYan YYin FZDove Medical Pressarticlecommunity-acquired pneumoniacurb-65pneumonia severity indexmortalitytype 2 diabetesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1359-1366 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	community-acquired pneumonia curb-65 pneumonia severity index mortality type 2 diabetes Specialties of internal medicine RC581-951
spellingShingle	community-acquired pneumonia curb-65 pneumonia severity index mortality type 2 diabetes Specialties of internal medicine RC581-951 Ma CM Wang N Su QW Yan Y Yin FZ The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population
description	Chun-Ming Ma,1 Ning Wang,2 Quan-Wei Su,3 Ying Yan,3 Fu-Zai Yin1 1Department of Endocrinology, The First Hospital of Qinhuangdao, Qinhuangdao, Hebei, People’s Republic of China; 2Department of Internal Medicine, Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Internal Medicine, Chengde Medical College, Chengde, Hebei, People’s Republic of ChinaCorrespondence: Fu-Zai Yin Email yinfuzai62@163.comObjective: To compare the performance of CURB-65 and Pneumonia Severity Index (PSI) for predicting in-hospital mortality of community-acquired pneumonia (CAP) between patients with and without type 2 diabetes (T2DM).Methods: A retrospective study was conducted on 2365 CAP patients in The First Hospital of Qinhuangdao, China. The primary outcome was in-hospital mortality. The area under curves (AUCs) was used to evaluate the abilities of CRB-65, CURB-65, and PSI class for predicting in-hospital mortality in patients with CAP.Results: Among CAP patients, 127 patients (5.4%) died, 80 patients were without diabetes, and 47 patients had T2DM. In-hospital mortality increased with the risk stratification defined as CURB-65 and PSI class in both non-diabetes and T2DM patients (P< 0.05). The AUCs for predicting in-hospital mortality were 0.728～0.798 in patients without T2DM (CRB-65: 0.728, CURB-65: 0.757 and PSI class: 0.798) and 0.641～0.716 in patients with T2DM (CRB-65: 0.641, CURB-65: 0.677 and PSI class: 0.716)(P< 0.001). The AUC of the PSI class was lower in patients with T2DM than in patients without T2DM (P< 0.05).Conclusion: CURB-65 and PSI class are correlated with in-hospital mortality of CAP in patients with and without T2DM. Compared with non-diabetes patients, the predictive performance of CURB-65 and PSI class decreased in patients with T2DM. A prediction model for evaluating the CAP severity in the T2DM population should be developed by future studies.Keywords: community-acquired pneumonia, CURB-65, pneumonia severity index, mortality, type 2 diabetes
format	article
author	Ma CM Wang N Su QW Yan Y Yin FZ
author_facet	Ma CM Wang N Su QW Yan Y Yin FZ
author_sort	Ma CM
title	The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population
title_short	The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population
title_full	The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population
title_fullStr	The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population
title_full_unstemmed	The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population
title_sort	performance of curb-65 and psi for predicting in-hospital mortality of community-acquired pneumonia in patients with type 2 diabetes compared with the non-diabetic population
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/88c59d4b9db54acbbeceedcc0eda9292
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The Performance of CURB-65 and PSI for Predicting In-Hospital Mortality of Community-Acquired Pneumonia in Patients with Type 2 Diabetes Compared with the Non-Diabetic Population

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