Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines

Jinqian Zhang,1,* Qiang Sun,2,* Jian Bo,3 Rui Huang,4 Mengran Zhang,1 Zhenglin Xia,4 Lili Ju,5 Guoan Xiang4 1Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China; 2Department of Nephrology, Beijing Children's Hospi...

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Autores principales:	Zhang JQ, Sun Q, Bo J, Huang R, Zhang MR, Xia ZL, Ju LL, Xiang GA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/88c68b4ebd2545caba02adb2b668a386
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spelling	oai:doaj.org-article:88c68b4ebd2545caba02adb2b668a3862021-12-02T01:30:29ZSingle-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines1178-2013https://doaj.org/article/88c68b4ebd2545caba02adb2b668a3862014-02-01T00:00:00Zhttp://www.dovepress.com/single-walled-carbon-nanohorn-swnh-aggregates-inhibited-proliferation--a15708https://doaj.org/toc/1178-2013 Jinqian Zhang,1,* Qiang Sun,2,* Jian Bo,3 Rui Huang,4 Mengran Zhang,1 Zhenglin Xia,4 Lili Ju,5 Guoan Xiang4 1Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China; 2Department of Nephrology, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China; 3Department of Hematology, Chinese PLA (People's Liberation Army) General Hospital, Beijing, People's Republic of China; 4Department of General Surgery, The Second People's Hospital of Guangdong Province, Southern Medical University, Guangzhou, People's Republic of China; 5Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Center of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, People's Republic of China *These authors contributed equally to this work Abstract: Single-walled carbon nanohorns (SWNHs) may be useful as carriers for anticancer drugs due to their particular structure. However, the interactions between the material itself and cancerous or normal cells have seldom been studied. To address this problem, the effects of raw SWNH material on the biological functions of human liver cell lines were studied. Our results showed that unmodified SWNHs inhibited mitotic entry, growth, and proliferation of human liver cell lines and promoted their apoptosis, especially in hepatoma cell lines. Individual spherical SWNH particles were found inside the nuclei of human hepatoma HepG2 cells and the lysosomes of normal human liver L02 cells, implying that SWNH particles could penetrate into human liver cells and the different interacted mechanisms on human normal cell lines compared to hepatoma cell lines. Further research on the mechanisms and application in treatment of hepatocellular carcinoma with SWNHs is needed. Keywords: single-walled carbon nanohorns, SWNHs, cell proliferation, cell apoptosis, hepatocellular carcinoma, nucleus, lysosomeZhang JQSun QBo JHuang RZhang MRXia ZLJu LLXiang GADove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 759-773 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Zhang JQ Sun Q Bo J Huang R Zhang MR Xia ZL Ju LL Xiang GA Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
description	Jinqian Zhang,1,* Qiang Sun,2,* Jian Bo,3 Rui Huang,4 Mengran Zhang,1 Zhenglin Xia,4 Lili Ju,5 Guoan Xiang4 1Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing, People's Republic of China; 2Department of Nephrology, Beijing Children's Hospital, Capital Medical University, Beijing, People's Republic of China; 3Department of Hematology, Chinese PLA (People's Liberation Army) General Hospital, Beijing, People's Republic of China; 4Department of General Surgery, The Second People's Hospital of Guangdong Province, Southern Medical University, Guangzhou, People's Republic of China; 5Department of Neurobiology, Beijing Institute for Brain Disorders, Beijing Center of Neural Regeneration and Repair, Key Laboratory for Neurodegenerative Diseases of the Ministry of Education, Capital Medical University, Beijing, People's Republic of China *These authors contributed equally to this work Abstract: Single-walled carbon nanohorns (SWNHs) may be useful as carriers for anticancer drugs due to their particular structure. However, the interactions between the material itself and cancerous or normal cells have seldom been studied. To address this problem, the effects of raw SWNH material on the biological functions of human liver cell lines were studied. Our results showed that unmodified SWNHs inhibited mitotic entry, growth, and proliferation of human liver cell lines and promoted their apoptosis, especially in hepatoma cell lines. Individual spherical SWNH particles were found inside the nuclei of human hepatoma HepG2 cells and the lysosomes of normal human liver L02 cells, implying that SWNH particles could penetrate into human liver cells and the different interacted mechanisms on human normal cell lines compared to hepatoma cell lines. Further research on the mechanisms and application in treatment of hepatocellular carcinoma with SWNHs is needed. Keywords: single-walled carbon nanohorns, SWNHs, cell proliferation, cell apoptosis, hepatocellular carcinoma, nucleus, lysosome
format	article
author	Zhang JQ Sun Q Bo J Huang R Zhang MR Xia ZL Ju LL Xiang GA
author_facet	Zhang JQ Sun Q Bo J Huang R Zhang MR Xia ZL Ju LL Xiang GA
author_sort	Zhang JQ
title	Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
title_short	Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
title_full	Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
title_fullStr	Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
title_full_unstemmed	Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
title_sort	single-walled carbon nanohorn (swnh) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/88c68b4ebd2545caba02adb2b668a386
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Single-walled carbon nanohorn (SWNH) aggregates inhibited proliferation of human liver cell lines and promoted apoptosis, especially for hepatoma cell lines

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