Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology

Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-galactosides. It has been described to be involved in apoptosis, proliferation and differentiation, but also in cell adhesion and migration. Several disorders and diseases are discussed by covering the aforementione...

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Autores principales:	Nishant V. Sewgobind, Sanne Albers, Roland J. Pieters
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	galectin-7 epithelial tissues apoptosis targeting inhibitors Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/88c7e836441a4b6db055832e3e1f52a1
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spelling	oai:doaj.org-article:88c7e836441a4b6db055832e3e1f52a12021-11-25T16:54:20ZFunctions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology10.3390/biom111117202218-273Xhttps://doaj.org/article/88c7e836441a4b6db055832e3e1f52a12021-11-01T00:00:00Zhttps://www.mdpi.com/2218-273X/11/11/1720https://doaj.org/toc/2218-273XGalectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-galactosides. It has been described to be involved in apoptosis, proliferation and differentiation, but also in cell adhesion and migration. Several disorders and diseases are discussed by covering the aforementioned biological processes. Structural features of galectin-7 are discussed as well as targeting the protein intracellularly or extracellularly. The exact molecular mechanisms that lie behind many biological processes involving galectin-7 are not known. It is therefore useful to come up with chemical probes or tools in order to obtain knowledge of the physiological processes. The objective of this review is to summarize the roles and functions of galectin-7 in the human body, providing reasons why it is necessary to design inhibitors for galectin-7, to give the reader structural insights and describe its current inhibitors.Nishant V. SewgobindSanne AlbersRoland J. PietersMDPI AGarticlegalectin-7epithelial tissuesapoptosistargetinginhibitorsMicrobiologyQR1-502ENBiomolecules, Vol 11, Iss 1720, p 1720 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	galectin-7 epithelial tissues apoptosis targeting inhibitors Microbiology QR1-502
spellingShingle	galectin-7 epithelial tissues apoptosis targeting inhibitors Microbiology QR1-502 Nishant V. Sewgobind Sanne Albers Roland J. Pieters Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
description	Galectin-7 is a soluble unglycosylated lectin that is able to bind specifically to β-galactosides. It has been described to be involved in apoptosis, proliferation and differentiation, but also in cell adhesion and migration. Several disorders and diseases are discussed by covering the aforementioned biological processes. Structural features of galectin-7 are discussed as well as targeting the protein intracellularly or extracellularly. The exact molecular mechanisms that lie behind many biological processes involving galectin-7 are not known. It is therefore useful to come up with chemical probes or tools in order to obtain knowledge of the physiological processes. The objective of this review is to summarize the roles and functions of galectin-7 in the human body, providing reasons why it is necessary to design inhibitors for galectin-7, to give the reader structural insights and describe its current inhibitors.
format	article
author	Nishant V. Sewgobind Sanne Albers Roland J. Pieters
author_facet	Nishant V. Sewgobind Sanne Albers Roland J. Pieters
author_sort	Nishant V. Sewgobind
title	Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
title_short	Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
title_full	Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
title_fullStr	Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
title_full_unstemmed	Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology
title_sort	functions and inhibition of galectin-7, an emerging target in cellular pathophysiology
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/88c7e836441a4b6db055832e3e1f52a1
work_keys_str_mv	AT nishantvsewgobind functionsandinhibitionofgalectin7anemergingtargetincellularpathophysiology AT sannealbers functionsandinhibitionofgalectin7anemergingtargetincellularpathophysiology AT rolandjpieters functionsandinhibitionofgalectin7anemergingtargetincellularpathophysiology
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Functions and Inhibition of Galectin-7, an Emerging Target in Cellular Pathophysiology

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