FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>

The yeast <i>Saccharomyces cerevisiae</i> has a remarkable ability to adapt its lifestyle to fluctuating or hostile environmental conditions. This adaptation most often involves morphological changes such as pseudofilaments, biofilm formation, or cell aggregation in the form of flocs. A...

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Autores principales: Clara Bouyx, Marion Schiavone, Jean Marie François
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Lenguaje:EN
Publicado: MDPI AG 2021
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Acceso en línea:https://doaj.org/article/88cb987c3dd24904b34f61a7221c0326
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spelling oai:doaj.org-article:88cb987c3dd24904b34f61a7221c03262021-11-25T18:38:49ZFLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>10.3390/pathogens101115092076-0817https://doaj.org/article/88cb987c3dd24904b34f61a7221c03262021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1509https://doaj.org/toc/2076-0817The yeast <i>Saccharomyces cerevisiae</i> has a remarkable ability to adapt its lifestyle to fluctuating or hostile environmental conditions. This adaptation most often involves morphological changes such as pseudofilaments, biofilm formation, or cell aggregation in the form of flocs. A prerequisite for these phenotypic changes is the ability to self-adhere and to adhere to abiotic surfaces. This ability is conferred by specialized surface proteins called flocculins, which are encoded by the <i>FLO</i> genes family in this yeast species. This mini-review focuses on the flocculin encoded by <i>FLO11</i>, which differs significantly from other flocculins in domain sequence and mode of genetic and epigenetic regulation, giving it an impressive plasticity that enables yeast cells to swiftly adapt to hostile environments or into new ecological niches. Furthermore, the common features of Flo11p with those of adhesins from pathogenic yeasts make <i>FLO11</i> a good model to study the molecular mechanism underlying cell adhesion and biofilm formation, which are part of the initial step leading to fungal infections.Clara BouyxMarion SchiavoneJean Marie FrançoisMDPI AGarticle<i>Saccharomyces cerevisiae</i>cell wallflocculinsadhesins<i>FLO11</i>phenotypic variationMedicineRENPathogens, Vol 10, Iss 1509, p 1509 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>Saccharomyces cerevisiae</i>
cell wall
flocculins
adhesins
<i>FLO11</i>
phenotypic variation
Medicine
R
spellingShingle <i>Saccharomyces cerevisiae</i>
cell wall
flocculins
adhesins
<i>FLO11</i>
phenotypic variation
Medicine
R
Clara Bouyx
Marion Schiavone
Jean Marie François
FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>
description The yeast <i>Saccharomyces cerevisiae</i> has a remarkable ability to adapt its lifestyle to fluctuating or hostile environmental conditions. This adaptation most often involves morphological changes such as pseudofilaments, biofilm formation, or cell aggregation in the form of flocs. A prerequisite for these phenotypic changes is the ability to self-adhere and to adhere to abiotic surfaces. This ability is conferred by specialized surface proteins called flocculins, which are encoded by the <i>FLO</i> genes family in this yeast species. This mini-review focuses on the flocculin encoded by <i>FLO11</i>, which differs significantly from other flocculins in domain sequence and mode of genetic and epigenetic regulation, giving it an impressive plasticity that enables yeast cells to swiftly adapt to hostile environments or into new ecological niches. Furthermore, the common features of Flo11p with those of adhesins from pathogenic yeasts make <i>FLO11</i> a good model to study the molecular mechanism underlying cell adhesion and biofilm formation, which are part of the initial step leading to fungal infections.
format article
author Clara Bouyx
Marion Schiavone
Jean Marie François
author_facet Clara Bouyx
Marion Schiavone
Jean Marie François
author_sort Clara Bouyx
title FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>
title_short FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>
title_full FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>
title_fullStr FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>
title_full_unstemmed FLO11, a Developmental Gene Conferring Impressive Adaptive Plasticity to the Yeast <i>Saccharomyces cerevisiae</i>
title_sort flo11, a developmental gene conferring impressive adaptive plasticity to the yeast <i>saccharomyces cerevisiae</i>
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/88cb987c3dd24904b34f61a7221c0326
work_keys_str_mv AT clarabouyx flo11adevelopmentalgeneconferringimpressiveadaptiveplasticitytotheyeastisaccharomycescerevisiaei
AT marionschiavone flo11adevelopmentalgeneconferringimpressiveadaptiveplasticitytotheyeastisaccharomycescerevisiaei
AT jeanmariefrancois flo11adevelopmentalgeneconferringimpressiveadaptiveplasticitytotheyeastisaccharomycescerevisiaei
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