Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.

Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wid...

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Autores principales: James Cheng-Chung Wei, Yu-Wen Hsu, Kuo-Sheng Hung, Ruey-Hong Wong, Chun-Huang Huang, Yi-Tzu Liu, Yuh-Cherng Guo, Shiro Ikegawa, Wei-Chiao Chang
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Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/88cd7a6eb41b4faa8cd77a5729f58961
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spelling oai:doaj.org-article:88cd7a6eb41b4faa8cd77a5729f589612021-11-18T08:02:41ZAssociation study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.1932-620310.1371/journal.pone.0052801https://doaj.org/article/88cd7a6eb41b4faa8cd77a5729f589612013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23308121/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G) and AS complications (uveitis and inflammatory bowel disease) were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.James Cheng-Chung WeiYu-Wen HsuKuo-Sheng HungRuey-Hong WongChun-Huang HuangYi-Tzu LiuYuh-Cherng GuoShiro IkegawaWei-Chiao ChangPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 1, p e52801 (2013)
institution DOAJ
collection DOAJ
language EN
topic Medicine
R
Science
Q
spellingShingle Medicine
R
Science
Q
James Cheng-Chung Wei
Yu-Wen Hsu
Kuo-Sheng Hung
Ruey-Hong Wong
Chun-Huang Huang
Yi-Tzu Liu
Yuh-Cherng Guo
Shiro Ikegawa
Wei-Chiao Chang
Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.
description Ankylosing spondylitis (AS) is a chronic inflammation of the sacroiliac joints, spine and peripheral joints. However, the development of anklosing spondylitis is unclear. Human leukocyte antigens HLA-B27 and ERAP1 have been widely reported to be associated with AS susceptibility. A recent genome-wide association study (GWAS) showed that two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569) and within ANO6 at 12q12 (rs17095830) contribute to the risk of AS in Han Chinese. In this study, we enrolled 475 AS patients and 475 healthy subjects to assess whether these genetic variations contribute to the susceptibility and the severity of AS in the Taiwanese population. The correlation between genetic polymorphisms, AS activity indexes, (namely, BASDAI, BASFI and BAS-G) and AS complications (uveitis and inflammatory bowel disease) were tested using the markers, rs4552569 and rs17095830. Although no association between rs4552569/rs17095830 genetic polymorphisms and AS susceptibility/severity was found, a significant association between rs17095830 and inflammatory bowel disease was observed in a Taiwanese population.
format article
author James Cheng-Chung Wei
Yu-Wen Hsu
Kuo-Sheng Hung
Ruey-Hong Wong
Chun-Huang Huang
Yi-Tzu Liu
Yuh-Cherng Guo
Shiro Ikegawa
Wei-Chiao Chang
author_facet James Cheng-Chung Wei
Yu-Wen Hsu
Kuo-Sheng Hung
Ruey-Hong Wong
Chun-Huang Huang
Yi-Tzu Liu
Yuh-Cherng Guo
Shiro Ikegawa
Wei-Chiao Chang
author_sort James Cheng-Chung Wei
title Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.
title_short Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.
title_full Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.
title_fullStr Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.
title_full_unstemmed Association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a Taiwanese population.
title_sort association study of polymorphisms rs4552569 and rs17095830 and the risk of ankylosing spondylitis in a taiwanese population.
publisher Public Library of Science (PLoS)
publishDate 2013
url https://doaj.org/article/88cd7a6eb41b4faa8cd77a5729f58961
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