Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials

Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials

Rainer Spiegel,1 Roger Kalla,2 Georgios Mantokoudis,3 Raphael Maire,4 Heiko Mueller,5 Robert Hoerr,5 Ralf Ihl6 1Division of Internal Medicine, Basel University Hospital, University of Basel, Basel, Switzerland; 2Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland; 3Dep...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Spiegel R, Kalla R, Mantokoudis G, Maire R, Mueller H, Hoerr R, Ihl R
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
neurodegenerative disorders
gait
unsteadiness
inner ear
hearing
review
Geriatrics
RC952-954.6
Acceso en línea:https://doaj.org/article/88cdab8aa66946199e67135c3b7b2513
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:88cdab8aa66946199e67135c3b7b2513
record_format dspace
spelling oai:doaj.org-article:88cdab8aa66946199e67135c3b7b25132021-12-02T08:01:22ZGinkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials1178-1998https://doaj.org/article/88cdab8aa66946199e67135c3b7b25132018-06-01T00:00:00Zhttps://www.dovepress.com/ginkgo-biloba-extract-egb-761reg-alleviates-neurosensory-symptoms-in-p-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Rainer Spiegel,1 Roger Kalla,2 Georgios Mantokoudis,3 Raphael Maire,4 Heiko Mueller,5 Robert Hoerr,5 Ralf Ihl6 1Division of Internal Medicine, Basel University Hospital, University of Basel, Basel, Switzerland; 2Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland; 3Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, Bern, Switzerland; 4Lausanne University Hospital, Lausanne, Switzerland; 5Clinical Research Department, Dr Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany; 6Department of Psychiatry, University of Duesseldorf, Alexian Research Center Krefeld, Krefeld, Germany Background: Tinnitus and dizziness are frequent in old age and often seen as concomitant symptoms in patients with dementia. In earlier clinical trials, Ginkgo biloba extract EGb 761® was found to alleviate tinnitus and dizziness in elderly patients. Consequently, a meta-analysis was conducted to evaluate the effects of EGb 761® at a daily dose of 240 mg on tinnitus and dizziness associated with dementia. Methods: Randomized, placebo-controlled clinical trials of G. biloba extract EGb 761® identified by a systematic database search were included in a meta-analysis if they met all of the following selection criteria: 1) diagnosis of dementia according to generally accepted criteria, 2) treatment period of at least 20 weeks, 3) outcome measures covering at least two of the three conventional domains of assessment, 4) presence and severity of dizziness and tinnitus were assessed, and 5) assessment was done before and after randomized treatment. Results: Five trials that met the inclusion criteria were included in the meta-analysis. The risk of bias was judged as low, with Jadad scores of 3 and 5. In all trials, 11-point box scales were used to assess the severity of tinnitus and dizziness. Overall, EGb 761® was superior to placebo, with weighted mean differences for change from baseline, calculated in meta-analyses using random effects models, of -1.06 (95% CI: -1.77, -0.36) for tinnitus (p = 0.003) and -0.77 (95% CI: -1.44, -0.09) for dizziness (p = 0.03). Conclusion: Our findings support the notion that EGb 761® is also effective in alleviating concomitant neurosensory symptoms in patients with dementia. Keywords: neurodegenerative disorders, gait, unsteadiness, inner ear, hearing, reviewSpiegel RKalla RMantokoudis GMaire RMueller HHoerr RIhl RDove Medical Pressarticleneurodegenerative disordersgaitunsteadinessinner earhearingreviewGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 13, Pp 1121-1127 (2018)
institution DOAJ
collection DOAJ
language EN
topic neurodegenerative disorders
gait
unsteadiness
inner ear
hearing
review
Geriatrics
RC952-954.6
spellingShingle neurodegenerative disorders
gait
unsteadiness
inner ear
hearing
review
Geriatrics
RC952-954.6
Spiegel R
Kalla R
Mantokoudis G
Maire R
Mueller H
Hoerr R
Ihl R
Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
description Rainer Spiegel,1 Roger Kalla,2 Georgios Mantokoudis,3 Raphael Maire,4 Heiko Mueller,5 Robert Hoerr,5 Ralf Ihl6 1Division of Internal Medicine, Basel University Hospital, University of Basel, Basel, Switzerland; 2Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland; 3Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, Bern, Switzerland; 4Lausanne University Hospital, Lausanne, Switzerland; 5Clinical Research Department, Dr Willmar Schwabe GmbH & Co. KG, Karlsruhe, Germany; 6Department of Psychiatry, University of Duesseldorf, Alexian Research Center Krefeld, Krefeld, Germany Background: Tinnitus and dizziness are frequent in old age and often seen as concomitant symptoms in patients with dementia. In earlier clinical trials, Ginkgo biloba extract EGb 761® was found to alleviate tinnitus and dizziness in elderly patients. Consequently, a meta-analysis was conducted to evaluate the effects of EGb 761® at a daily dose of 240 mg on tinnitus and dizziness associated with dementia. Methods: Randomized, placebo-controlled clinical trials of G. biloba extract EGb 761® identified by a systematic database search were included in a meta-analysis if they met all of the following selection criteria: 1) diagnosis of dementia according to generally accepted criteria, 2) treatment period of at least 20 weeks, 3) outcome measures covering at least two of the three conventional domains of assessment, 4) presence and severity of dizziness and tinnitus were assessed, and 5) assessment was done before and after randomized treatment. Results: Five trials that met the inclusion criteria were included in the meta-analysis. The risk of bias was judged as low, with Jadad scores of 3 and 5. In all trials, 11-point box scales were used to assess the severity of tinnitus and dizziness. Overall, EGb 761® was superior to placebo, with weighted mean differences for change from baseline, calculated in meta-analyses using random effects models, of -1.06 (95% CI: -1.77, -0.36) for tinnitus (p = 0.003) and -0.77 (95% CI: -1.44, -0.09) for dizziness (p = 0.03). Conclusion: Our findings support the notion that EGb 761® is also effective in alleviating concomitant neurosensory symptoms in patients with dementia. Keywords: neurodegenerative disorders, gait, unsteadiness, inner ear, hearing, review
format article
author Spiegel R
Kalla R
Mantokoudis G
Maire R
Mueller H
Hoerr R
Ihl R
author_facet Spiegel R
Kalla R
Mantokoudis G
Maire R
Mueller H
Hoerr R
Ihl R
author_sort Spiegel R
title Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
title_short Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
title_full Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
title_fullStr Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
title_full_unstemmed Ginkgo biloba extract EGb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
title_sort ginkgo biloba extract egb 761® alleviates neurosensory symptoms in patients with dementia: a meta-analysis of treatment effects on tinnitus and dizziness in randomized, placebo-controlled trials
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/88cdab8aa66946199e67135c3b7b2513
work_keys_str_mv AT spiegelr ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
AT kallar ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
AT mantokoudisg ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
AT mairer ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
AT muellerh ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
AT hoerrr ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
AT ihlr ginkgobilobaextractegb761regalleviatesneurosensorysymptomsinpatientswithdementiaametaanalysisoftreatmenteffectsontinnitusanddizzinessinrandomizedplacebocontrolledtrials
_version_ 1718398734609416192

Ejemplares similares