IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development

Abstract Among various cytokines, interleukin (IL)-12 family cytokines have very unique characteristics in that they are composed of two distinct subunits and these subunits are shared with each other. IL-23, one of the IL-12 family cytokines, consists of p19 and p40 subunits, is mainly produced by...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hideaki Hasegawa, Izuru Mizoguchi, Naoko Orii, Shinya Inoue, Yasuhiro Katahira, Toshihiko Yoneto, Mingli Xu, Toru Miyazaki, Takayuki Yoshimoto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88cfd12351954441be5fab9535e4e725
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:88cfd12351954441be5fab9535e4e725
record_format	dspace
spelling	oai:doaj.org-article:88cfd12351954441be5fab9535e4e7252021-12-02T15:54:10ZIL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development10.1038/s41598-021-84624-92045-2322https://doaj.org/article/88cfd12351954441be5fab9535e4e7252021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84624-9https://doaj.org/toc/2045-2322Abstract Among various cytokines, interleukin (IL)-12 family cytokines have very unique characteristics in that they are composed of two distinct subunits and these subunits are shared with each other. IL-23, one of the IL-12 family cytokines, consists of p19 and p40 subunits, is mainly produced by antigen-presenting cells, and plays a critical role in the expansion and maintenance of pathogenic helper CD4+ T (Th)17 cells. Since we initially found that p19 is secreted in the culture supernatant of activated CD4+ T cells, we have further investigated the role of p19. p19 was revealed to associate with CD5 antigen-like (CD5L), which is a repressor of Th17 pathogenicity and is highly expressed in non-pathogenic Th17 cells, to form a composite p19/CD5L. This p19/CD5L was shown to activate STAT5 and enhance the differentiation into granulocyte macrophage colony-stimulating factor (GM-CSF)-producing CD4+ T cells. Both CD4+ T cell-specific conditional p19-deficient mice and complete CD5L-deficient mice showed significantly alleviated experimental autoimmune encephalomyelitis (EAE) with reduced frequency of GM-CSF+CD4+ T cells. During the course of EAE, the serum level of p19/CD5L, but not CD5L, correlated highly with the clinical symptoms. Thus, the composite p19/CD5L is a possible novel heterodimeric cytokine that contributes to EAE development with GM-CSF up-regulation.Hideaki HasegawaIzuru MizoguchiNaoko OriiShinya InoueYasuhiro KatahiraToshihiko YonetoMingli XuToru MiyazakiTakayuki YoshimotoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hideaki Hasegawa Izuru Mizoguchi Naoko Orii Shinya Inoue Yasuhiro Katahira Toshihiko Yoneto Mingli Xu Toru Miyazaki Takayuki Yoshimoto IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
description	Abstract Among various cytokines, interleukin (IL)-12 family cytokines have very unique characteristics in that they are composed of two distinct subunits and these subunits are shared with each other. IL-23, one of the IL-12 family cytokines, consists of p19 and p40 subunits, is mainly produced by antigen-presenting cells, and plays a critical role in the expansion and maintenance of pathogenic helper CD4+ T (Th)17 cells. Since we initially found that p19 is secreted in the culture supernatant of activated CD4+ T cells, we have further investigated the role of p19. p19 was revealed to associate with CD5 antigen-like (CD5L), which is a repressor of Th17 pathogenicity and is highly expressed in non-pathogenic Th17 cells, to form a composite p19/CD5L. This p19/CD5L was shown to activate STAT5 and enhance the differentiation into granulocyte macrophage colony-stimulating factor (GM-CSF)-producing CD4+ T cells. Both CD4+ T cell-specific conditional p19-deficient mice and complete CD5L-deficient mice showed significantly alleviated experimental autoimmune encephalomyelitis (EAE) with reduced frequency of GM-CSF+CD4+ T cells. During the course of EAE, the serum level of p19/CD5L, but not CD5L, correlated highly with the clinical symptoms. Thus, the composite p19/CD5L is a possible novel heterodimeric cytokine that contributes to EAE development with GM-CSF up-regulation.
format	article
author	Hideaki Hasegawa Izuru Mizoguchi Naoko Orii Shinya Inoue Yasuhiro Katahira Toshihiko Yoneto Mingli Xu Toru Miyazaki Takayuki Yoshimoto
author_facet	Hideaki Hasegawa Izuru Mizoguchi Naoko Orii Shinya Inoue Yasuhiro Katahira Toshihiko Yoneto Mingli Xu Toru Miyazaki Takayuki Yoshimoto
author_sort	Hideaki Hasegawa
title	IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
title_short	IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
title_full	IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
title_fullStr	IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
title_full_unstemmed	IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
title_sort	il-23p19 and cd5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88cfd12351954441be5fab9535e4e725
work_keys_str_mv	AT hideakihasegawa il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT izurumizoguchi il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT naokoorii il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT shinyainoue il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT yasuhirokatahira il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT toshihikoyoneto il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT minglixu il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT torumiyazaki il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment AT takayukiyoshimoto il23p19andcd5antigenlikeformapossiblenovelheterodimericcytokineandcontributetoexperimentalautoimmuneencephalomyelitisdevelopment
_version_	1718385460261158912

IL-23p19 and CD5 antigen-like form a possible novel heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development

Ejemplares similares