Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.

T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune response. The killing apparatus can also osci...

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Autores principales:	Mun Ju Kim, Ivan V Maly
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2009
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/88d03e8813af4722872ff210f0ec3489
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spelling	oai:doaj.org-article:88d03e8813af4722872ff210f0ec34892021-11-25T05:41:54ZDeterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.1553-734X1553-735810.1371/journal.pcbi.1000260https://doaj.org/article/88d03e8813af4722872ff210f0ec34892009-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19132078/?tool=EBIhttps://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune response. The killing apparatus can also oscillate next to the cell-cell interface. When two target cells are engaged by the T cell simultaneously, the killing apparatus can oscillate between the two interface areas. This oscillation is one of the most striking examples of cell movements that give the microscopist an unmechanistic impression of the cell's fidgety indecision. We have constructed a three-dimensional, numerical biomechanical model of the molecular-motor-driven microtubule cytoskeleton that positions the killing apparatus. The model demonstrates that the cortical pulling mechanism is indeed capable of orienting the killing apparatus into the functional position under a range of conditions. The model also predicts experimentally testable limitations of this commonly hypothesized mechanism of T-cell polarization. After the reorientation, the numerical solution exhibits complex, multidirectional, multiperiodic, and sustained oscillations in the absence of any external guidance or stochasticity. These computational results demonstrate that the strikingly animate wandering of aim in T-killer cells has a purely mechanical and deterministic explanation.Mun Ju KimIvan V MalyPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 5, Iss 1, p e1000260 (2009)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Mun Ju Kim Ivan V Maly Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
description	T-killer cells of the immune system eliminate virus-infected and tumorous cells through direct cell-cell interactions. Reorientation of the killing apparatus inside the T cell to the T-cell interface with the target cell ensures specificity of the immune response. The killing apparatus can also oscillate next to the cell-cell interface. When two target cells are engaged by the T cell simultaneously, the killing apparatus can oscillate between the two interface areas. This oscillation is one of the most striking examples of cell movements that give the microscopist an unmechanistic impression of the cell's fidgety indecision. We have constructed a three-dimensional, numerical biomechanical model of the molecular-motor-driven microtubule cytoskeleton that positions the killing apparatus. The model demonstrates that the cortical pulling mechanism is indeed capable of orienting the killing apparatus into the functional position under a range of conditions. The model also predicts experimentally testable limitations of this commonly hypothesized mechanism of T-cell polarization. After the reorientation, the numerical solution exhibits complex, multidirectional, multiperiodic, and sustained oscillations in the absence of any external guidance or stochasticity. These computational results demonstrate that the strikingly animate wandering of aim in T-killer cells has a purely mechanical and deterministic explanation.
format	article
author	Mun Ju Kim Ivan V Maly
author_facet	Mun Ju Kim Ivan V Maly
author_sort	Mun Ju Kim
title	Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
title_short	Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
title_full	Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
title_fullStr	Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
title_full_unstemmed	Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
title_sort	deterministic mechanical model of t-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.
publisher	Public Library of Science (PLoS)
publishDate	2009
url	https://doaj.org/article/88d03e8813af4722872ff210f0ec3489
work_keys_str_mv	AT munjukim deterministicmechanicalmodeloftkillercellpolarizationreproducesthewanderingofaimbetweensimultaneouslyengagedtargets AT ivanvmaly deterministicmechanicalmodeloftkillercellpolarizationreproducesthewanderingofaimbetweensimultaneouslyengagedtargets
_version_	1718414527565922304

Deterministic mechanical model of T-killer cell polarization reproduces the wandering of aim between simultaneously engaged targets.

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