Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases

CDP-diacylglycerol (CDP-DAG) alcohol O-phosphatidyl transferases (CDP-APs) are conserved in archaea, bacteria, and eukaryotes and catalyze the de novo synthesis of phospho-lipids from the precursor CDP-DAG and an alcohol. Here, the authors present the crystal structures of the Methanocaldococcus jan...

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Autores principales:	Martin Centola, Katharina van Pee, Heidi Betz, Özkan Yildiz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/88d1806c720c42119e5e570066d05712
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spelling	oai:doaj.org-article:88d1806c720c42119e5e570066d057122021-12-05T12:22:59ZCrystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases10.1038/s41467-021-27281-w2041-1723https://doaj.org/article/88d1806c720c42119e5e570066d057122021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27281-whttps://doaj.org/toc/2041-1723CDP-diacylglycerol (CDP-DAG) alcohol O-phosphatidyl transferases (CDP-APs) are conserved in archaea, bacteria, and eukaryotes and catalyze the de novo synthesis of phospho-lipids from the precursor CDP-DAG and an alcohol. Here, the authors present the crystal structures of the Methanocaldococcus jannaschii phosphatidyl serine synthase (MjPSS) in four different states and suggest a model for its catalytic mechanism.Martin CentolaKatharina van PeeHeidi BetzÖzkan YildizNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Martin Centola Katharina van Pee Heidi Betz Özkan Yildiz Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
description	CDP-diacylglycerol (CDP-DAG) alcohol O-phosphatidyl transferases (CDP-APs) are conserved in archaea, bacteria, and eukaryotes and catalyze the de novo synthesis of phospho-lipids from the precursor CDP-DAG and an alcohol. Here, the authors present the crystal structures of the Methanocaldococcus jannaschii phosphatidyl serine synthase (MjPSS) in four different states and suggest a model for its catalytic mechanism.
format	article
author	Martin Centola Katharina van Pee Heidi Betz Özkan Yildiz
author_facet	Martin Centola Katharina van Pee Heidi Betz Özkan Yildiz
author_sort	Martin Centola
title	Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
title_short	Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
title_full	Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
title_fullStr	Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
title_full_unstemmed	Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases
title_sort	crystal structures of phosphatidyl serine synthase pss reveal the catalytic mechanism of cdp-dag alcohol o-phosphatidyl transferases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88d1806c720c42119e5e570066d05712
work_keys_str_mv	AT martincentola crystalstructuresofphosphatidylserinesynthasepssrevealthecatalyticmechanismofcdpdagalcoholophosphatidyltransferases AT katharinavanpee crystalstructuresofphosphatidylserinesynthasepssrevealthecatalyticmechanismofcdpdagalcoholophosphatidyltransferases AT heidibetz crystalstructuresofphosphatidylserinesynthasepssrevealthecatalyticmechanismofcdpdagalcoholophosphatidyltransferases AT ozkanyildiz crystalstructuresofphosphatidylserinesynthasepssrevealthecatalyticmechanismofcdpdagalcoholophosphatidyltransferases
_version_	1718371968830406656

Crystal structures of phosphatidyl serine synthase PSS reveal the catalytic mechanism of CDP-DAG alcohol O-phosphatidyl transferases

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