Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding

Functional variants have been proposed to alter transcription factor binding. Here, the authors provide direct evidence that functional variants within the TBC1D4 gene, encoding an NFκB binding site, can alter transcription factor binding, and use CRISPR-Cas9 to reveal localization of the transcript...

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Auteurs principaux:	Andrew D. Johnston, Claudia A. Simões-Pires, Taylor V. Thompson, Masako Suzuki, John M. Greally
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/88d29a982eee4fd9b508af61899db295
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spelling	oai:doaj.org-article:88d29a982eee4fd9b508af61899db2952021-12-02T15:35:31ZFunctional genetic variants can mediate their regulatory effects through alteration of transcription factor binding10.1038/s41467-019-11412-52041-1723https://doaj.org/article/88d29a982eee4fd9b508af61899db2952019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11412-5https://doaj.org/toc/2041-1723Functional variants have been proposed to alter transcription factor binding. Here, the authors provide direct evidence that functional variants within the TBC1D4 gene, encoding an NFκB binding site, can alter transcription factor binding, and use CRISPR-Cas9 to reveal localization of the transcription factor to be the regulator of chromatin accessibility and p65 binding and ultimately TBC1D4 expression.Andrew D. JohnstonClaudia A. Simões-PiresTaylor V. ThompsonMasako SuzukiJohn M. GreallyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Andrew D. Johnston Claudia A. Simões-Pires Taylor V. Thompson Masako Suzuki John M. Greally Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
description	Functional variants have been proposed to alter transcription factor binding. Here, the authors provide direct evidence that functional variants within the TBC1D4 gene, encoding an NFκB binding site, can alter transcription factor binding, and use CRISPR-Cas9 to reveal localization of the transcription factor to be the regulator of chromatin accessibility and p65 binding and ultimately TBC1D4 expression.
format	article
author	Andrew D. Johnston Claudia A. Simões-Pires Taylor V. Thompson Masako Suzuki John M. Greally
author_facet	Andrew D. Johnston Claudia A. Simões-Pires Taylor V. Thompson Masako Suzuki John M. Greally
author_sort	Andrew D. Johnston
title	Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
title_short	Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
title_full	Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
title_fullStr	Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
title_full_unstemmed	Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
title_sort	functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/88d29a982eee4fd9b508af61899db295
work_keys_str_mv	AT andrewdjohnston functionalgeneticvariantscanmediatetheirregulatoryeffectsthroughalterationoftranscriptionfactorbinding AT claudiaasimoespires functionalgeneticvariantscanmediatetheirregulatoryeffectsthroughalterationoftranscriptionfactorbinding AT taylorvthompson functionalgeneticvariantscanmediatetheirregulatoryeffectsthroughalterationoftranscriptionfactorbinding AT masakosuzuki functionalgeneticvariantscanmediatetheirregulatoryeffectsthroughalterationoftranscriptionfactorbinding AT johnmgreally functionalgeneticvariantscanmediatetheirregulatoryeffectsthroughalterationoftranscriptionfactorbinding
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Functional genetic variants can mediate their regulatory effects through alteration of transcription factor binding

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