A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate

Abstract Emergence of nanotechnology created a drastic change in the field of cancer therapy due to their unique features in drug delivery and imaging. Polysaccharide based nanoparticles have received extensive attention in recent years as promising nanoparticle mediated drug delivery systems. Polys...

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Autores principales:	B. S. Unnikrishnan, G. U. Preethi, T. T. Sreelekha
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/88d33dee3f764ffa9d1eef2ab3a22a82
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spelling	oai:doaj.org-article:88d33dee3f764ffa9d1eef2ab3a22a822021-12-02T17:32:58ZA comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate10.1038/s41598-021-87364-y2045-2322https://doaj.org/article/88d33dee3f764ffa9d1eef2ab3a22a822021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87364-yhttps://doaj.org/toc/2045-2322Abstract Emergence of nanotechnology created a drastic change in the field of cancer therapy due to their unique features in drug delivery and imaging. Polysaccharide based nanoparticles have received extensive attention in recent years as promising nanoparticle mediated drug delivery systems. Polysaccharides are endorsed with versatile merits including high drug encapsulation efficiency, efficient drug protection against chemical or enzymatic degradation, unique ability to create a controlled release and cellular internalization. In the current study, we have fabricated doxorubicin-loaded carboxymethylated PST001 coated iron oxide nanoparticles (DOX@CM-PST-IONPs) for better management of cancer. CM-PST coated iron oxide nanoparticles co-encapsulated with chemotherapeutic drug doxorubicin, can be utilized for targeted drug delivery. Biocompatible and non-toxic nanoconjugates was found to be effective in both 2-D and 3-D cell culture system with efficient cancer cell internalization. The bench-marked potential of CM-PIONPs to produce reactive oxygen species makes it a noticeable drug delivery system to compact neoplasia. These nanoconjugates can lay concrete on a better way for the elimination of cancer spheroids and tumor burden.B. S. UnnikrishnanG. U. PreethiT. T. SreelekhaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q B. S. Unnikrishnan G. U. Preethi T. T. Sreelekha A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
description	Abstract Emergence of nanotechnology created a drastic change in the field of cancer therapy due to their unique features in drug delivery and imaging. Polysaccharide based nanoparticles have received extensive attention in recent years as promising nanoparticle mediated drug delivery systems. Polysaccharides are endorsed with versatile merits including high drug encapsulation efficiency, efficient drug protection against chemical or enzymatic degradation, unique ability to create a controlled release and cellular internalization. In the current study, we have fabricated doxorubicin-loaded carboxymethylated PST001 coated iron oxide nanoparticles (DOX@CM-PST-IONPs) for better management of cancer. CM-PST coated iron oxide nanoparticles co-encapsulated with chemotherapeutic drug doxorubicin, can be utilized for targeted drug delivery. Biocompatible and non-toxic nanoconjugates was found to be effective in both 2-D and 3-D cell culture system with efficient cancer cell internalization. The bench-marked potential of CM-PIONPs to produce reactive oxygen species makes it a noticeable drug delivery system to compact neoplasia. These nanoconjugates can lay concrete on a better way for the elimination of cancer spheroids and tumor burden.
format	article
author	B. S. Unnikrishnan G. U. Preethi T. T. Sreelekha
author_facet	B. S. Unnikrishnan G. U. Preethi T. T. Sreelekha
author_sort	B. S. Unnikrishnan
title	A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
title_short	A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
title_full	A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
title_fullStr	A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
title_full_unstemmed	A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate
title_sort	comprehensive study on 2d, 3d and solid tumor environment to explore a multifunctional biogenic nanoconjugate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/88d33dee3f764ffa9d1eef2ab3a22a82
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A comprehensive study on 2D, 3D and solid tumor environment to explore a multifunctional biogenic nanoconjugate

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